Colts vs. Titans Week 6 Dunkel NFL Picks, Predictions and Odds

Having dropped one straight, the Tennessee Titans (0-5) will face the Indianapolis Colts (2-3). The Colts are solid favorites, expected to win by at least a touchdown (currently -7). The over/under for this one is set at 44.5 points.

With 384.2 yards allowed per game on defense, which ranks fifth-worst in the NFL, the Colts have been forced to lean on their 24th-ranked offense (293.8 yards per contest) to keep them in games. The Titans rank worst in points per game (11.6), but they've been more productive on the other side of the ball, ranking 10th in the NFL with 21.8 points surrendered per contest.

Colts vs. Titans Odds and Game Time

• Date: Sunday, October 18, 2026
• Time: 1 p.m. ET
• City: Indianapolis, Indiana
• Venue: Lucas Oil Stadium
• Total: 44.5 points
• Spread: Colts -7
• Moneyline: Colts (-325), Titans (+260)

How to watch Colts vs. Titans

• TV Channel: FOX

Betting the Over/Under: Colts vs. Titans

• The Colts and their opponents have scored more than 44.5 total points three times this season.
• So far this season, three of Indianapolis' five games have gone over the point total.
• The Titans have not played a game this season that finished with a combined score higher than 44.5 points.
• So far this season, just one Tennessee game has hit the over.
• These two teams rack up a combined 36.4 points per game, 8.1 fewer points than this matchup's point total.
• Opponents of these teams score 49.4 points per game combined, 4.9 more points than this matchup's over/under.

Betting the Spread: Colts vs. Titans

• Indianapolis has put together a 3-2-0 record against the spread this season.
• The Titans have won two games against the spread this season.
• Tennessee has been an underdog by 7 points or more two times this season, and covered the spread both times.

Betting the Moneyline: Colts vs. Titans

• Indianapolis has been the moneyline favorite just one other time so far this season, a game they won.
• This season, the Titans have been listed as the underdog in four games and failed to win any of those contests.
• Indianapolis has not yet played as a moneyline favorite of -325 or shorter.
• Tennessee has played as an underdog of +260 or more once this season and lost that game.
• Based on this matchup's moneyline, the Colts have an implied win probability of 76.5%.

Dunkel Prediction for Colts vs. Titans

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