Astros vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - April 18

The Houston Astros host the St. Louis Cardinals at 7:10 p.m. ET on Saturday, featuring two top-10 sluggers. Yordan Alvarez has eight homers (first in league) for the Astros, while Jordan Walker is first with eight home runs for the Cardinals. Lance McCullers (1-0, 5.87 ERA) will start for the Astros, who are 8-13 this season and fourth in the AL West. Andre Pallante (1-1, 4.80 ERA) is expected to start for the Cardinals, who are 11-8 and fourth in the NL Central.

The oddsmakers have spoken, making the Astros (-128) a moderate moneyline favorite to defeat the Cardinals (+108) at home. The over/under for the Astros-Cardinals game is set at 9.

Astros vs. Cardinals Odds, Game Time

• Game day: Saturday, April 18, 2026
• Game time: 7:10 p.m. ET
• Location: Houston, Texas
• Stadium: Daikin Park
• Favorite: Astros (-128)
• Underdog: Cardinals (+108)
• Over/under: 9

How to Watch Astros vs. Cardinals

• TV Channel: SCHN and CARD
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Astros vs. Cardinals: Betting the Moneyline

• The Astros have a 5-9 record in games they were listed as the moneyline favorite (winning 35.7% of those games).
• St. Louis has been underdogs in 16 games this season and has come away with the win nine times (56.2%) in those contests.
• This season Houston has won five of its 13 games, or 38.5%, when favored by at least -128 on the moneyline.
• The Cardinals have a mark of 5-4 in contests where sportsbooks favor them by +108 or worse on the moneyline.
• The implied moneyline probablility in this matchup gives the Astros a 56.1% chance to win.
• The moneyline set for this matchup implies the Cardinals have a 48.1% chance of walking away with the win.

Astros vs. Cardinals: Betting the Spread & Total

• The Astros have played in 21 games with an over/under set, and have combined with their opponents to go over the total 14 times (14-7-0).
• So far this season, St. Louis and its opponents have hit the over in 10 of its 19 games with a total.
• The Astros have covered just 38.1% of their games this season, going 8-13-0 against the spread.
• The Cardinals have an against the spread record of 10-9-0 in 19 games with a line this season.