Tigers vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - May 21

The Cleveland Guardians will attempt to keep a five-game winning streak going when they visit the Detroit Tigers at 1:10 p.m. ET on Thursday. Casey Mize (2-2, 2.43 ERA) will start for the Tigers, who are 20-30 this season and fourth in the AL Central. Joey Cantillo (3-1, 3.40 ERA) is starting for the Guardians, who are 29-22 and first in the AL Central.

The Tigers (-120) are moneyline favorites at home over the Guardians (+100). The contest has an over/under set at 7.

Tigers vs. Guardians Odds, Game Time

• Game day: Thursday, May 21, 2026
• Game time: 1:10 p.m. ET
• Location: Detroit, Michigan
• Stadium: Comerica Park
• Favorite: Tigers (-120)
• Underdog: Guardians (+100)
• Over/under: 7

How to Watch Tigers vs. Guardians

• TV Channel: DSN and CLEG
• Live Stream: Fubo (Watch for free)

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Tigers vs. Guardians: Betting the Moneyline

• The Tigers are 13-14 in games they were favored on the moneyline (winning 48.1% of those games).
• Cleveland has been pegged as an underdog in 22 games this year and has walked away with the win 12 times (54.5%) in those games.
• Detroit has a record of 13-8 in games when bookmakers favor them by at least -120 on the moneyline.
• The Guardians have a mark of 11-8 in contests where sportsbooks favor them by +100 or worse on the moneyline.
• Based on this game's moneyline, the Tigers' implied win probability is 54.5%.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 50% chance of pulling out a win.

Tigers vs. Guardians: Betting the Spread & Total

• The Tigers have combined with opponents to go over the total 22 times this season for a 22-26-2 record against the over/under.
• Cleveland and its opponents have gone over the total this season in 26 of its 51 opportunities.
• The Tigers have collected a 25-25-0 record against the spread this season (covering 50% of the time).
• In 51 games with a line this season, the Guardians have a mark of 28-23-0 against the spread.