Lions vs. Cardinals Week 5 Dunkel NFL Picks, Predictions and Odds

The Detroit Lions (2-2) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5) over the Arizona Cardinals (1-3). The Cardinals have lost three games straight. The game has an over/under of 54.5 points.

Despite having a bottom-five defense that ranks worst in the NFL (423.8 yards allowed per game), the Lions have played better on the other side of the ball, ranking sixth in the NFL by totaling 389.3 yards per game. The Cardinals rank 22nd with 294.8 total yards per game on offense, and they rank 24th with 351.3 total yards ceded per contest on the defensive side of the ball.

Lions vs. Cardinals Odds and Game Time

• Date: Sunday, October 11, 2026
• Time: 4:25 p.m. ET
• City: Glendale, Arizona
• Venue: State Farm Stadium
• Total: 54.5 points
• Spread: Lions -5.5
• Moneyline: Lions (-250), Cardinals (+205)

How to watch Lions vs. Cardinals

• TV Channel: FOX

Betting the Over/Under: Lions vs. Cardinals

• Each Lions game this season has had a combined score above 54.5 total points.
• So far this season, each Detroit game has hit the over.
• The Cardinals and their opponents have scored more than 54.5 combined points twice this season.
• Arizona games have hit the over twice this year.
• These teams average 51.6 points per game combined, 2.9 less than this game's total.
• Opponents of these two teams put up 61.1 points per game combined, 6.6 more points than this contest's total.

Betting the Spread: Lions vs. Cardinals

• Detroit has not won against the spread this season in four opportunities.
• Detroit has been favored by 5.5 points or more this season twice, and failed to cover both times.
• The Cardinals have a record of 2-2-0 against the spread this year.
• Arizona has covered the spread when playing as at least 5.5-point underdogs in two of two chances this season.

Betting the Moneyline: Lions vs. Cardinals

• Detroit has compiled a 2-1 record in games they were favored on the moneyline (winning 66.7% of those games).
• This season, the Cardinals have won one out of the three games in which they've been the underdog.
• Detroit has played as a moneyline favorite of -250 or shorter in just two games this season, and it won both.
• Arizona has a record of 1-1 when it is set as an underdog of +205 or more by bookmakers this season.
• The Lions have a 71.4% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Lions vs. Cardinals

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