Guardians vs. Tigers Dunkel MLB Picks, Predictions and Prop Bets - May 20

The Detroit Tigers hope to break their four-game losing run against the Cleveland Guardians, at 6:40 p.m. ET on Wednesday. Tanner Bibee (0-6, 4.15 ERA) will start for the Guardians, who are 28-22 this season and first in the AL Central. Drew Anderson (1-1, 4.67 ERA) is starting for the Tigers, who are 20-29 and fourth in the AL Central.

Even though the Guardians are playing on the road at the Tigers, they are currently favored on the moneyline at -120, compared to the home team at +101. The contest has a total set at 7.5.

Guardians vs. Tigers Odds, Game Time

• Game day: Wednesday, May 20, 2026
• Game time: 6:40 p.m. ET
• Location: Detroit, Michigan
• Stadium: Comerica Park
• Favorite: Guardians (-120)
• Underdog: Tigers (+101)
• Over/under: 7.5

How to Watch Guardians vs. Tigers

• TV Channel: DSN and CLEG
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Tigers: Betting the Moneyline

• The Guardians have been the moneyline favorite 28 total times this season. They've gone 16-12 in those games.
• Detroit has come away with seven wins in the 20 contests it has been listed as the underdogs in this season.
• This season Cleveland has won 13 of its 23 games, or 56.5%, when favored by at least -120 on the moneyline.
• This season, the Tigers have been victorious six times in 17 chances when named as an underdog of at least +101 or worse on the moneyline.
• The Guardians have an implied moneyline win probability of 54.5% in this contest.
• The moneyline set for this matchup implies the Tigers have a 49.8% chance of coming away with a victory in the contest.

Guardians vs. Tigers: Betting the Spread & Total

• The Guardians have had an over/under set by oddsmakers 50 times, and have combined with opponents to go over the total in 26 of those games (26-24-0).
• Games involving Detroit have gone over the total set by sportsbooks in 22 of 49 chances this season.
• The Guardians have collected a 28-22-0 record ATS this season (covering 56% of the time).
• The Tigers have posted a record of 24-25-0 against the spread this season.