Guardians vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - May 17

The Cleveland Guardians host the Cincinnati Reds at 1:40 p.m. ET on Sunday, with both teams hoping to win the series. Gavin Williams (5-3, 3.74 ERA) will start for the Guardians, who are 25-22 this season and first in the AL Central. Brady Singer (2-3, 5.79 ERA) is starting for the Reds, who are 24-22 and fifth in the NL Central.

The sportsbooks have spoken, making the Guardians (-162) a moderate moneyline favorite to beat the Reds (+135) at home. The game has an over/under set at 8.5 runs.

Guardians vs. Reds Odds, Game Time

• Game day: Sunday, May 17, 2026
• Game time: 1:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-162)
• Underdog: Reds (+135)
• Over/under: 8.5

How to Watch Guardians vs. Reds

• TV Channel: CLEG and CINR
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Reds: Betting the Moneyline

• The Guardians have gone 14-12 in games they were favored on the moneyline (winning 53.8% of those games).
• Cincinnati has been underdogs in 30 games this season and has come away with the win 15 times (50%) in those contests.
• Cleveland has played as favorites of -162 or more twice this season and split those games.
• The Reds have a mark of 2-4 in contests where bookmakers favor them by +135 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Guardians a 61.8% chance to win.
• The moneyline set for this matchup implies the Reds have a 42.6% chance of walking away with the win.

Guardians vs. Reds: Betting the Spread & Total

• The Guardians have played in 47 games with set over/under, and have combined with opponents to go over the total 24 times (24-23-0).
• Cincinnati and its opponents have hit the over in 29 of its 46 games with a total this season.
• The Guardians have gone 26-21-0 ATS this season.
• In 46 games with a line this season, the Reds have a mark of 28-18-0 against the spread.