Guardians vs. Red Sox Dunkel MLB Picks, Predictions and Prop Bets - May 29

The Cleveland Guardians host the Boston Red Sox to start a three-game series at Progressive Field, with first pitch at 7:10 p.m. ET on Friday. Slade Cecconi (3-5, 5.18 ERA) will start for the Guardians, who are 33-25 this season and first in the AL Central. Tyler Samaniego (0-2, 1.04 ERA) is expected to start for the Red Sox, who are 23-32 and fifth in the AL East.

The Guardians are moderate favorites on the moneyline (-130) at home over the Red Sox (+109). The total for the Guardians-Red Sox game is 8.

Guardians vs. Red Sox Odds, Game Time

• Game day: Friday, May 29, 2026
• Game time: 7:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-130)
• Underdog: Red Sox (+109)
• Over/under: 8

How to Watch Guardians vs. Red Sox

• TV Channel: CLEG and NESN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Red Sox: Betting the Moneyline

• The Guardians have compiled a 19-14 record in games they were listed as the moneyline favorite (winning 57.6% of those games).
• Boston has been pegged as an underdog in 19 games this year and has walked away with the win seven times (36.8%) in those games.
• This season Cleveland has won 11 of its 19 games, or 57.9%, when favored by at least -130 on the moneyline.
• The Red Sox have a mark of 3-8 in contests where sportsbooks favor them by +109 or worse on the moneyline.
• The Guardians have a 56.5% chance to win this contest based on the moneyline's implied probability.
• The moneyline set for this matchup implies the Red Sox have a 47.8% chance of walking away with the win.

Guardians vs. Red Sox: Betting the Spread & Total

• The Guardians have played in 58 games with a set over/under, and have combined with their opponents to go over the total 28 times (28-30-0).
• Boston and its opponents have hit the over in 24 of its 55 games with a total this season.
• The Guardians have collected a 31-27-0 record against the spread this season (covering 53.4% of the time).
• The Red Sox are 22-33-0 against the spread in their 55 games with a line set by sportsbooks this season.