White Sox vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - May 22

The San Francisco Giants carry a three-game losing streak into a contest versus the Chicago White Sox, at 10:15 p.m. ET on Friday. Davis Martin (6-1, 1.61 ERA) will start for the White Sox, who are 25-24 this season and second in the AL Central. Trevor McDonald (2-0, 2.37 ERA) is starting for the Giants, who are 20-30 and fourth in the NL West.

With moneyline odds of -113 for the White Sox versus -106 for the Giants, this game should be a close one. The total in this contest is set at 7.5.

White Sox vs. Giants Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 10:15 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: White Sox (-113)
• Underdog: Giants (-106)
• Over/under: 7.5

How to Watch White Sox vs. Giants

• TV Channel: NBCS-BA and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

White Sox vs. Giants: Betting the Moneyline

• The White Sox have won two of the five games they were listed as the moneyline favorite this season (40%).
• San Francisco has won in 13, or 37.1%, of the 35 contests it has been named as odds-on underdogs in this year.
• Chicago has a record of 2-3 when favored by -113 or more by oddsmakers this season.
• The Giants have a mark of 13-19 in contests where sportsbooks favor them by -106 or worse on the moneyline.
• The White Sox have an implied moneyline win probability of 53.1% in this matchup.
• The moneyline set for this matchup implies the Giants have a 51.5% chance of walking away with the win.

White Sox vs. Giants: Betting the Spread & Total

• The White Sox have had an over/under set by bookmakers 49 times, and have combined with opponents to go over the total in 28 of those games (28-20-1).
• San Francisco's games have gone over the total in 22 of its 50 chances.
• The White Sox have gone 29-20-0 ATS this season.
• The Giants have an against the spread mark of 20-30-0 in 50 games with a line this season.