Cubs vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - May 29

The Chicago Cubs and St. Louis Cardinals clash in the first of a three-game series on Friday at Busch Stadium, at 7:15 p.m. ET. Shota Imanaga (4-5, 4.04 ERA) gets the start for the Cubs, who are 31-26 this season and second in the NL Central. Andre Pallante (5-4, 3.76 ERA) is expected to start for the Cardinals, who are 29-25 and third in the NL Central.

Sportsbooks have set the Cubs as the moderate moneyline favorites (-131) on the road versus the Cardinals (+110). The game has an over/under set at 7.5 runs.

Cubs vs. Cardinals Odds, Game Time

• Game day: Friday, May 29, 2026
• Game time: 7:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cubs (-131)
• Underdog: Cardinals (+110)
• Over/under: 7.5

How to Watch Cubs vs. Cardinals

• TV Channel: CARD and MARQ
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. Cardinals: Betting the Moneyline

• The Cubs have won 55.3% of the games this season when they were favored on the moneyline (21-17).
• St. Louis has been pegged as an underdog in 46 games this year and has walked away with the win 25 times (54.3%) in those games.
• Chicago is 16-11 this season when entering a game favored by -131 or more on the moneyline.
• This season, the Cardinals have been victorious 15 times in 31 chances when named as an underdog of at least +110 or longer on the moneyline.
• Based on this matchup's moneyline, the Cubs' implied win probability is 56.7%.
• Bookmakers have implied with the moneyline set for this matchup that the Cardinals have a 47.6% chance of pulling out a win.

Cubs vs. Cardinals: Betting the Spread & Total

• In the 57 games in which bookmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 32 times (32-23-2).
• St. Louis and its opponents have gone over the total this season in 21 of its 54 opportunities.
• The Cubs have collected a 23-34-0 record ATS this season (covering 40.4% of the time).
• The Cardinals have an against the spread mark of 32-22-0 in 54 games with a line this season.