Cubs vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - May 23

The Chicago Cubs will try to stop a five-game losing streak when hosting the Houston Astros at 2:20 p.m. ET on Saturday. Colin Rea (4-2, 4.98 ERA) gets the start for the Cubs, who are 29-21 this season and second in the NL Central. Kai-Wei Teng (2-3, 2.61 ERA) is starting for the Astros, who are 20-31 and fourth in the AL West.

The Cubs are moderate favorites on the moneyline (-142) at home over the Astros (+120).

Cubs vs. Astros Odds, Game Time

• Game day: Saturday, May 23, 2026
• Game time: 2:20 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-142)
• Underdog: Astros (+120)

How to Watch Cubs vs. Astros

• TV Channel: MARQ and SCHN
• Live Stream: Fubo (Watch for free)

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Cubs vs. Astros: Betting the Moneyline

• The Cubs have gone 21-13 in games they were listed as the moneyline favorite (winning 61.8% of those games).
• Houston has won in 15, or 42.9%, of the 35 contests it has been named as odds-on underdogs in this year.
• Chicago is 12-6 this season when entering a game favored by -142 or more on the moneyline.
• This year, the Astros have won five of 16 games when listed as at least +120 or worse on the moneyline.
• The Cubs have a 58.7% chance to win this game based on the moneyline's implied probability.
• The moneyline set for this matchup implies the Astros have a 45.5% chance of coming away with a victory in the contest.

Cubs vs. Astros: Betting the Spread & Total

• In the 50 games in which oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 28 times (28-20-2).
• Houston and its opponents have hit the over in 28 of its 51 games with a total this season.
• The Cubs have collected a 21-29-0 record against the spread this season (covering 42% of the time).
• In 51 games with a line this season, the Astros have a mark of 20-31-0 against the spread.