Cubs vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - May 23

The Chicago Cubs will attempt to stop a six-game losing streak when hosting the Houston Astros at 2:20 p.m. ET on Saturday. Colin Rea (4-2, 4.98 ERA) will start for the Cubs, who are 29-22 this season and third in the NL Central. Kai-Wei Teng (2-3, 2.61 ERA) is starting for the Astros, who are 21-31 and fourth in the AL West.

The Cubs (-152) are moneyline favorites at home over the Astros (+127). The contest has an over/under set at 7.5.

Cubs vs. Astros Odds, Game Time

• Game day: Saturday, May 23, 2026
• Game time: 2:20 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-152)
• Underdog: Astros (+127)
• Over/under: 7.5

How to Watch Cubs vs. Astros

• TV Channel: MARQ and SCHN
• Live Stream: Fubo (Watch for free)

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Cubs vs. Astros: Betting the Moneyline

• The Cubs have been favored on the moneyline 35 total times this season. They've gone 21-14 in those games.
• Houston has come away with 16 wins in the 36 contests it has been listed as the underdogs in this season.
• Chicago has a record of 11-4 in games when bookmakers favor them by at least -152 on the moneyline.
• This year, the Astros have won three of 14 games when listed as at least +127 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Cubs a 60.3% chance to win.
• The moneyline set for this matchup implies the Astros have a 44.1% chance of coming away with a victory in the contest.

Cubs vs. Astros: Betting the Spread & Total

• The Cubs have combined with opponents to hit the over on the total 28 times this season for a 28-21-2 record against the over/under.
• Games involving Houston have gone over the total set by sportsbooks in 28 of 52 chances this season.
• The Cubs have collected a 21-30-0 record ATS this season.
• The Astros have an against the spread mark of 21-31-0 in 52 games with a line this season.