Cubs vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - May 22

The Chicago Cubs and Houston Astros square off in the first of a three-game series on Friday at Wrigley Field, at 2:20 p.m. ET. Jameson Taillon (2-3, 4.97 ERA) gets the start for the Cubs, who are 29-21 this season and second in the NL Central. Spencer Arrighetti (5-1, 1.50 ERA) is starting for the Astros, who are 20-31 and fourth in the AL West.

At home, the Cubs are favored to win on the moneyline (-141) over the Astros (+118). The contest has a total set at 7.

Cubs vs. Astros Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 2:20 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-141)
• Underdog: Astros (+118)
• Over/under: 7

How to Watch Cubs vs. Astros

• TV Channel: Apple TV+
• Live Stream: Fubo (Watch for free)

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Cubs vs. Astros: Betting the Moneyline

• The Cubs have a 21-13 record in games they were favored on the moneyline (winning 61.8% of those games).
• Houston has won in 15, or 42.9%, of the 35 contests it has been named as odds-on underdogs in this year.
• This season Chicago has won 13 of its 19 games, or 68.4%, when favored by at least -141 on the moneyline.
• This season, the Astros have come away with a win five times in 16 chances when named as an underdog of at least +118 or longer on the moneyline.
• Based on this game's moneyline, the Cubs have an implied win probability of 58.5%.
• The Astros have an implied victory probability of 45.9% according to the moneyline set for this matchup.

Cubs vs. Astros: Betting the Spread & Total

• In the 50 games in which bookmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 28 times (28-20-2).
• So far this season, Houston and its opponents have hit the over in 28 of its 51 games with a total.
• The Cubs have a 21-29-0 record against the spread this season.
• In 51 games with a line this season, the Astros have a mark of 20-31-0 against the spread.