Cubs vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - April 5

The Cleveland Guardians will look to Gabriel Arias, on a two-game homer streak, versus the Chicago Cubs at 1:10 p.m. ET on Sunday, at Progressive Field. Edward Cabrera (1-0, 0.00 ERA) will start for the Cubs, who are 3-4 this season and fifth in the NL Central. Slade Cecconi (0-1, 12.46 ERA) is the expected starter for the Guardians, who are 5-3 and first in the AL Central.

Despite playing away from their home ballpark, the Cubs are favored to win (-133) over the Guardians (+112). The game has an over/under set at 7.5 runs.

Cubs vs. Guardians Odds, Game Time

• Game day: Sunday, April 5, 2026
• Game time: 1:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Cubs (-133)
• Underdog: Guardians (+112)
• Over/under: 7.5

How to Watch Cubs vs. Guardians

• TV Channel: CLEG and MARQ
• Live Stream: Fubo (Watch for free)

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Cubs vs. Guardians: Betting the Moneyline

• The Cubs have won three of the seven games they were favored on the moneyline this season (42.9%).
• Cleveland has been pegged as an underdog in eight games this year and has walked away with the win five times (62.5%) in those games.
• This season Chicago has won three of its six games when favored by at least -133 on the moneyline.
• This year, the Guardians have won four of seven games when listed as at least +112 or worse on the moneyline.
• The implied moneyline probablility in this matchup gives the Cubs a 57.1% chance to win.
• The Guardians have an implied victory probability of 47.2% according to the moneyline set by oddsmakers for this matchup.

Cubs vs. Guardians: Betting the Spread & Total

• The Cubs have had an over/under set by bookmakers seven times, and have combined with opponents to go over the total in three of those games (3-3-1).
• Cleveland's games have gone over the total in three of its eight chances.
• The Cubs have a 3-4-0 record against the spread this season (covering 42.9% of the time).
• The Guardians are 5-3-0 against the spread in their eight games with a line set by sportsbooks this season.