Cubs vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - April 3

The Chicago Cubs and Cleveland Guardians square off in the first of a three-game series on Friday at Progressive Field, at 4:10 p.m. ET. Cade Horton (1-0, 2.84 ERA) will start for the Cubs, who are 3-3 this season and third in the NL Central. Joey Cantillo (0-0, 4.91 ERA) is the expected starter for the Guardians, who are 4-3 and first in the AL Central.

Per the moneyline, the matchup between the Cubs (-119) and Guardians (-100) looks like a close one. The contest has an over/under set at 7.5.

Cubs vs. Guardians Odds, Game Time

• Game day: Friday, April 3, 2026
• Game time: 4:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Cubs (-119)
• Underdog: Guardians (-100)
• Over/under: 7.5

How to Watch Cubs vs. Guardians

• TV Channel: CLEG and MARQ
• Live Stream: Fubo (Watch for free)

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Cubs vs. Guardians: Betting the Moneyline

• The Cubs have won three of the six games they were favored on the moneyline this season (50%).
• Cleveland has come away with four wins in the seven contests it has been listed as the underdogs in this season.
• Chicago has a record of 3-3 when favored by -119 or more by bookmakers this season.
• The Guardians have a win-loss record of 4-3 when favored by -100 or worse by sportsbooks this year.
• The Cubs have an implied moneyline win probability of 54.3% in this matchup.
• The moneyline set for this matchup implies the Guardians have a 50% chance of walking away with the win.

Cubs vs. Guardians: Betting the Spread & Total

• The Cubs have had an over/under set by oddsmakers six times, and have combined with opponents to go over the total in three of those games (3-2-1).
• Cleveland's games have gone over the total in three of its seven chances.
• The Cubs are 3-3-0 ATS this season.
• The Guardians are 4-3-0 against the spread in their seven games that had a posted line this season.