Red Sox vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - May 22

The Boston Red Sox and Minnesota Twins square off on Friday at 7:10 p.m. ET, beginning a three-game series at Fenway Park. Payton Tolle (2-2, 2.05 ERA) will start for the Red Sox, who are 22-27 this season and fourth in the AL East. Connor Prielipp (1-2, 2.88 ERA) is starting for the Twins, who are 23-27 and third in the AL Central.

The Red Sox are moderate favorites on the moneyline (-153) at home over the Twins (+128). The game's total is 7.5.

Red Sox vs. Twins Odds, Game Time

• Game day: Friday, May 22, 2026
• Game time: 7:10 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Red Sox (-153)
• Underdog: Twins (+128)
• Over/under: 7.5

How to Watch Red Sox vs. Twins

• TV Channel: NESN and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Red Sox vs. Twins: Betting the Moneyline

• The Red Sox are 15-16 in games they were favored on the moneyline (winning 48.4% of those games).
• Minnesota has come away with 16 wins in the 34 contests it has been listed as the underdogs in this season.
• This season Boston has won two of its five games when favored by at least -153 on the moneyline.
• This year, the Twins have won seven of 11 games when listed as at least +128 or worse on the moneyline.
• Based on this game's moneyline, the Red Sox have an implied win probability of 60.5%.
• The moneyline set for this matchup implies the Twins have a 43.9% chance of coming away with a victory in the contest.

Red Sox vs. Twins: Betting the Spread & Total

• The Red Sox have combined with opponents to hit the over on the total 20 times this season for a 20-27-2 record against the over/under.
• So far this season, Minnesota and its opponents have hit the over in 27 of its 50 games with a total.
• The Red Sox have covered 40.8% of their games this season, going 20-29-0 ATS.
• The Twins are 26-24-0 against the spread in their 50 games with a line set by sportsbooks this season.