Red Sox vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - Sept. 24

The Boston Red Sox host the Cleveland Guardians at 6:45 p.m. ET on Thursday, with both teams hoping to win the series. Ranger Suarez (8-4, 3.27 ERA) will start for the Red Sox, who are 85-73 this season and third in the AL East. Daniel Espino (0-0, 4.73 ERA) is expected to start for the Guardians, who are 82-76 and first in the AL Central.

Bookmakers have made the Red Sox a decent moneyline favorite (-131) at home over the Guardians (+108). The game has an over/under set at 6.5 runs.

Red Sox vs. Guardians Odds, Game Time

• Game day: Thursday, September 24, 2026
• Game time: 6:45 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Red Sox (-131)
• Underdog: Guardians (+108)
• Over/under: 6.5

How to Watch Red Sox vs. Guardians

• TV Channel: NESN and CLEG
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Red Sox vs. Guardians: Betting the Moneyline

• The Red Sox have put together a 61-50 record in games they were favored on the moneyline (winning 55% of those games).
• Cleveland has been pegged as an underdog in 60 games this year and has walked away with the win 29 times (48.3%) in those games.
• Boston has a record of 38-33 in games when bookmakers favor them by at least -131 on the moneyline.
• The Guardians have a mark of 20-17 in contests where oddsmakers favor them by +108 or worse on the moneyline.
• Based on this game's moneyline, the Red Sox's implied win probability is 56.7%.
• Sportsbooks have implied with the moneyline set for this matchup that the Guardians have a 48.1% chance of pulling out a win.

Red Sox vs. Guardians: Betting the Spread & Total

• The Red Sox have played in 158 games with an over/under set, and have combined with their opponents to go over the total 69 times (69-84-5).
• So far this season, Cleveland and its opponents have hit the over in 75 of its 158 games with a total.
• The Red Sox have covered 47.5% of their games this season, going 75-83-0 against the spread.
• In 158 games with a line this season, the Guardians have a mark of 76-82-0 against the spread.