Diamondbacks vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - Aug. 21

The Arizona Diamondbacks host the Cincinnati Reds to open a three-game series at Chase Field, with first pitch at 9:40 p.m. ET on Friday. Eduardo Rodriguez (12-4, 2.71 ERA) gets the start for the Diamondbacks, who are 67-61 this season and third in the NL West. Nick Lodolo (3-2, 4.52 ERA) is the expected starter for the Reds, who are 61-67 and fifth in the NL Central.

The Diamondbacks are moderate favorites on the moneyline (-145) at home over the Reds (+128). The over/under in this contest is 8.5.

Diamondbacks vs. Reds Odds, Game Time

• Game day: Friday, August 21, 2026
• Game time: 9:40 p.m. ET
• Location: Phoenix, Arizona
• Stadium: Chase Field
• Favorite: Diamondbacks (-145)
• Underdog: Reds (+128)
• Over/under: 8.5

How to Watch Diamondbacks vs. Reds

• TV Channel: ARID and CINR
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Diamondbacks vs. Reds: Betting the Moneyline

• The Diamondbacks have a 31-21 record in games they were favored on the moneyline (winning 59.6% of those games).
• Cincinnati has been pegged as an underdog in 87 games this year and has walked away with the win 38 times (43.7%) in those games.
• Arizona is 9-8 this season when entering a game favored by -145 or more on the moneyline.
• This season, the Reds have been victorious seven times in 20 chances when named as an underdog of at least +128 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Diamondbacks a 59.2% chance to win.
• The moneyline set for this matchup implies the Reds have a 43.9% chance of walking away with the win.

Diamondbacks vs. Reds: Betting the Spread & Total

• In the 128 games in which bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 56 times (56-67-5).
• Cincinnati and its opponents have gone over the total this season in 67 of its 128 opportunities.
• The Diamondbacks have gone 70-58-0 against the spread this season.
• The Reds are 67-61-0 against the spread in their 128 games that had a posted line this season.