Syracuse vs. Virginia Tech Dunkel Predictions & Vegas Odds - Jan. 21

The Syracuse Orange (12-6, 3-2 ACC) host the Virginia Tech Hokies (14-5, 3-3 ACC) at JMA Wireless Dome, starting at 9 p.m. ET on Wednesday, January 21, 2026. The Orange are 3.5-point favorites in the game. The matchup's over/under is set at 151.5.

Syracuse is coming off of an 81-73 OT loss to Boston College in its most recent outing on Saturday. Nate Kingz totaled 27 points, six rebounds and three assists for Syracuse. Virginia Tech is coming off of an 89-76 victory over Notre Dame in its last outing on Saturday. In Virginia Tech's win, Toibu Lawal led the way with 22 points (adding 11 rebounds and zero assists).

Syracuse vs. Virginia Tech Odds and Game Time

• When: Wednesday, January 21, 2026 at 9 p.m. ET
• Where: JMA Wireless Dome in Syracuse, New York
• Spread favorite: Syracuse -3.5
• Moneyline favorite: Syracuse -173
• Moneyline underdog: Virginia Tech +144
• Over/Under: 151.5 points

How to watch Syracuse vs. Virginia Tech

• TV Channel: ACC Network
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Syracuse vs. Virginia Tech

• Seven of Syracuse's games this season have gone over Wednesday's total of 151.5 points.
• There have been 13 Virginia Tech games that ended with a combined score over 151.5 points this season.
• The over/under for the contest of 151.5 is 6.5 points fewer than the combined points per game averages for the Orange (75.7) and Hokies (82.3).
• These two teams give up a combined 141.8 points per game, 9.7 less than this contest's over/under.
• Syracuse has seen a 143.4 average over/under in its games this season, 8.1 less than the over/under in this matchup.
• The over/under for this game is 4.9 points lower than the average over/under in Virginia Tech's games this season (156.4 points).

Betting the Spread: Syracuse vs. Virginia Tech

• Syracuse has nine wins against the spread in 18 games this year.
• The Orange have been favored by 3.5 points or more 11 times this season and are 5-6 ATS in those contests.
• Against the spread, Virginia Tech is 11-8-0 this season.
• The Hokies have been underdogs by 3.5 points or more four times this season and are 3-1 ATS in those matchups.
• Syracuse is 5-6 against the spread, and 9-2 overall, at home.
• As a 3.5-point favorite or greater at home, Syracuse is 4-5 ATS.
• Virginia Tech is 3-0 against the spread, and 1-2 overall, on the road.

Betting the Moneyline: Syracuse vs. Virginia Tech

• Syracuse has been the moneyline favorite in 12 games this season and won 10 (83.3%) of those contests.
• This season, the Orange have won nine of their 11 games, or 81.8%, when favored by at least -173 on the moneyline.
• The moneyline for this contest implies a 63.4% chance of a victory for Syracuse.
• Virginia Tech has won in three of the seven contests it has been named as the moneyline underdog this year.
• This season, the Hokies have been victorious one time in four chances when named as an underdog of at least +144 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that Virginia Tech has a 41% chance of pulling out a win.