Cardinals vs. Guardians Dunkel MLB Picks, Predictions and Prop Bets - April 15

The St. Louis Cardinals are looking for Jordan Walker to extend a 10-game hitting streak versus the Cleveland Guardians on Wednesday at 1:15 p.m. ET, at Busch Stadium. Dustin May (1-2, 9.45 ERA) will start for the Cardinals, who are 9-8 this season and third in the NL Central. Slade Cecconi (0-2, 5.74 ERA) is expected to start for the Guardians, who are 10-8 and second in the AL Central.

With moneyline odds of -112 for the Cardinals and -108 for the Guardians, this could be a close contest. The contest has a total set at 8.5.

Cardinals vs. Guardians Odds, Game Time

• Game day: Wednesday, April 15, 2026
• Game time: 1:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: Cardinals (-112)
• Underdog: Guardians (-108)
• Over/under: 8.5

How to Watch Cardinals vs. Guardians

• TV Channel: CARD and CLEG
• Live Stream: Fubo (Watch for free)

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Cardinals vs. Guardians: Betting the Moneyline

• The Cardinals have been listed as the moneyline favorite just two other times so far this season, and they split the two games.
• Cleveland has come away with eight wins in the 14 contests it has been listed as the underdogs in this season.
• St. Louis has played as favorites of -112 or more twice this season and split those games.
• This season, the Guardians have come away with a win eight times in 14 chances when named as an underdog of at least -108 or worse on the moneyline.
• Based on this game's moneyline, the Cardinals' implied win probability is 52.8%.
• The Guardians have an implied victory probability of 51.9% according to the moneyline set for this matchup.

Cardinals vs. Guardians: Betting the Spread & Total

• The Cardinals have combined with opponents to hit the over on the total nine times this season for a 9-6-2 record against the over/under.
• Games involving Cleveland have gone over the total set by oddsmakers in nine of 18 chances this season.
• The Cardinals have covered 47.1% of their games this season, going 8-9-0 ATS.
• The Guardians have an against the spread mark of 11-7-0 in 18 games with a line this season.