Mariners vs. Padres Dunkel MLB Picks, Predictions and Prop Bets - April 16

The San Diego Padres will aim to keep a seven-game winning streak going when they host the Seattle Mariners at 8:40 p.m. ET on Thursday. Luis Castillo (0-0, 6.92 ERA) will start for the Mariners, who are 8-11 this season and fifth in the AL West. Walker Buehler (0-1, 4.97 ERA) is expected to start for the Padres, who are 12-6 and second in the NL West.

The Mariners are currently a moderate moneyline favorite (-120) on the road at the Padres (+100). The contest has an over/under set at 8.5.

Mariners vs. Padres Odds, Game Time

• Game day: Thursday, April 16, 2026
• Game time: 8:40 p.m. ET
• Location: San Diego, California
• Stadium: Petco Park
• Favorite: Mariners (-120)
• Underdog: Padres (+100)
• Over/under: 8.5

How to Watch Mariners vs. Padres

• TV Channel: MLB Network, SDPA and SEAM
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Mariners vs. Padres: Betting the Moneyline

• The Mariners have won 46.7% of the games this season when they were the moneyline favorite (7-8).
• San Diego has come away with four wins in the eight contests it has been listed as the underdogs in this season.
• This season Seattle has won seven of its 14 games, or 50%, when favored by at least -120 on the moneyline.
• The Padres have a mark of 4-4 in contests where sportsbooks favor them by +100 or worse on the moneyline.
• Based on this game's moneyline, the Mariners' implied win probability is 54.5%.
• The Padres have an implied victory probability of 50% according to the moneyline set for this matchup.

Mariners vs. Padres: Betting the Spread & Total

• The Mariners have combined with opponents to go over the total nine times this season for a 9-10-0 record against the over/under.
• San Diego's games have gone over the total in nine of its 18 chances.
• The Mariners have covered just 36.8% of their games this season, going 7-12-0 against the spread.
• The Padres are 13-5-0 against the spread in their 18 games that had a posted line this season.