Mariners vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - May 13

The Houston Astros hope to break their four-game losing run versus the Seattle Mariners, at 8:10 p.m. ET on Wednesday. Bryce Miller (0-0, 0.00 ERA) gets the start for the Mariners, who are 21-22 this season and second in the AL West. Lance McCullers (2-3, 7.41 ERA) is expected to start for the Astros, who are 16-27 and fifth in the AL West.

Despite playing away from their home ballpark, the Mariners are favored to win (-128) over the Astros (+108). The over/under for the Mariners-Astros game is 9.

Mariners vs. Astros Odds, Game Time

• Game day: Wednesday, May 13, 2026
• Game time: 8:10 p.m. ET
• Location: Houston, Texas
• Stadium: Daikin Park
• Favorite: Mariners (-128)
• Underdog: Astros (+108)
• Over/under: 9

How to Watch Mariners vs. Astros

• TV Channel: SCHN and SEAM
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Mariners vs. Astros: Betting the Moneyline

• The Mariners are 20-19 in games they were favored on the moneyline (winning 51.3% of those games).
• Houston has come away with 11 wins in the 27 contests it has been listed as the underdogs in this season.
• Seattle has a record of 20-12, a 62.5% win rate, when favored by -128 or more by oddsmakers this season.
• This season, the Astros have come away with a win nine times in 23 chances when named as an underdog of at least +108 or worse on the moneyline.
• The Mariners have an implied moneyline win probability of 56.1% in this contest.
• The Astros have an implied victory probability of 48.1% according to the moneyline set by sportsbooks for this matchup.

Mariners vs. Astros: Betting the Spread & Total

• The Mariners have played in 43 games with set over/under, and have combined with opponents to go over the total 19 times (19-23-1).
• Houston and its opponents have gone over the total this season in 27 of its 43 opportunities.
• The Mariners are 16-27-0 against the spread this season.
• The Astros are 16-27-0 against the spread in their 43 games that had a posted line this season.