Mariners vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - July 22

The Cincinnati Reds will look to Nathaniel Lowe, on a two-game homer streak, against the Seattle Mariners at 3:40 p.m. ET on Wednesday, at T-Mobile Park. Emerson Hancock (6-4, 3.17 ERA) will start for the Mariners, who are 51-51 this season and second in the AL West. Brady Singer (4-9, 4.56 ERA) is expected to start for the Reds, who are 46-54 and fifth in the NL Central.

Oddsmakers expect a close matchup between the Mariners (-120 to win) and the Reds (-102). The over/under for the Mariners-Reds game is 7.5.

Mariners vs. Reds Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 3:40 p.m. ET
• Location: Seattle, Washington
• Stadium: T-Mobile Park
• Favorite: Mariners (-120)
• Underdog: Reds (-102)
• Over/under: 7.5

How to Watch Mariners vs. Reds

• TV Channel: SEAM and CINR
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Mariners vs. Reds: Betting the Moneyline

• The Mariners have won 54% of the games this season when they were the moneyline favorite (47-40).
• Cincinnati has been underdogs in 68 games this season and has come away with the win 29 times (42.6%) in those contests.
• Seattle has a record of 43-35 in games when bookmakers favor them by at least -120 on the moneyline.
• This season, the Reds have come away with a win 21 times in 58 chances when named as an underdog of at least -102 or longer on the moneyline.
• The implied moneyline probablility in this matchup gives the Mariners a 54.5% chance to win.
• Oddsmakers have implied with the moneyline set for this matchup that the Reds have a 50.5% chance of pulling out a win.

Mariners vs. Reds: Betting the Spread & Total

• In the 102 games in which oddsmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 49 times (49-47-6).
• Cincinnati and its opponents have hit the over in 56 of its 100 games with a total this season.
• The Mariners have covered just 39.2% of their games this season, going 40-62-0 ATS.
• The Reds have an against the spread mark of 54-46-0 in 100 games with a line this season.