Giants vs. Royals Dunkel MLB Picks, Predictions and Prop Bets - July 22

The San Francisco Giants take a four-game losing run into a road matchup versus the Kansas City Royals, at 2:10 p.m. ET on Wednesday. Landen Roupp (7-8, 3.98 ERA) will start for the Giants, who are 42-59 this season and fourth in the NL West. Seth Lugo (3-6, 4.39 ERA) is expected to start for the Royals, who are 42-60 and fifth in the AL Central.

Despite playing on the road, the Giants are still a decent moneyline favorite (-122) over the Royals (+100). The over/under in this contest is set at 9.

Giants vs. Royals Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 2:10 p.m. ET
• Location: Kansas City, Missouri
• Stadium: Kauffman Stadium
• Favorite: Giants (-122)
• Underdog: Royals (+100)
• Over/under: 9

How to Watch Giants vs. Royals

• TV Channel: ROYL and NBCS-BA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Giants vs. Royals: Betting the Moneyline

• The Giants have gone 18-20 in games they were favored on the moneyline (winning 47.4% of those games).
• Kansas City has come away with 25 wins in the 66 contests it has been listed as the underdogs in this season.
• San Francisco has a record of 12-11, a 52.2% win rate, when favored by -122 or more by sportsbooks this season.
• This season, the Royals have been victorious 18 times in 49 chances when named as an underdog of at least +100 or worse on the moneyline.
• The Giants have a 55% chance to win this matchup based on the moneyline's implied probability.
• The moneyline set for this matchup implies the Royals have a 50% chance of walking away with the win.

Giants vs. Royals: Betting the Spread & Total

• The Giants have had an over/under set by bookmakers 100 times, and have combined with opponents to go over the total in 46 of those games (46-46-8).
• Kansas City's games have gone over the total in 49 of its 102 chances.
• The Giants have a 46-54-0 record against the spread this season.
• The Royals have posted a record of 44-58-0 against the spread this season.