Giants vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - April 15

The San Francisco Giants will attempt to snap a three-game losing streak when visiting the Cincinnati Reds at 6:40 p.m. ET on Wednesday. Tyler Mahle (0-2, 4.30 ERA) gets the start for the Giants, who are 6-11 this season and fifth in the NL West. Rhett Lowder (1-1, 3.31 ERA) is expected to start for the Reds, who are 10-7 and first in the NL Central.

The moneyline odds for the Giants (-110) versus the Reds (-109) are tight. The over/under in this contest is 9.5.

Giants vs. Reds Odds, Game Time

• Game day: Wednesday, April 15, 2026
• Game time: 6:40 p.m. ET
• Location: Cincinnati, Ohio
• Stadium: Great American Ball Park
• Favorite: Giants (-110)
• Underdog: Reds (-109)
• Over/under: 9.5

How to Watch Giants vs. Reds

• TV Channel: CINR and NBCS-BA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Giants vs. Reds: Betting the Moneyline

• The Giants have been favored on the moneyline four total times this season. They've finished 1-3 in those games.
• Cincinnati has come away with seven wins in the 13 contests it has been listed as the underdogs in this season.
• San Francisco is 1-3 this season when entering a game favored by -110 or more on the moneyline.
• This season, the Reds have been victorious seven times in 13 chances when named as an underdog of at least -109 or worse on the moneyline.
• The Giants have an implied moneyline win probability of 52.4% in this contest.
• Bookmakers have implied with the moneyline set for this matchup that the Reds have a 52.2% chance of pulling out a win.

Giants vs. Reds: Betting the Spread & Total

• The Giants have had an over/under set by oddsmakers 17 times, and have combined with opponents to go over the total in seven of those games (7-7-3).
• Cincinnati and its opponents have gone over the total this season in nine of its 17 opportunities.
• The Giants have covered just 29.4% of their games this season, going 5-12-0 against the spread.
• The Reds are 10-7-0 against the spread in their 17 games with a line set by sportsbooks this season.