San Francisco 49ers at Tennessee Titans Betting Preview

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— Thursday, December 23rd San Francisco 49ers @ Tennessee Titans

Week 16 of the NFL season is loaded with important games, and the action gets started on Thursday night with a great matchup. The Tennessee Titans host the San Francisco 49ers, and both teams are in need of a win to inch closer to the postseason.

San Francisco got off to a slow start in 2021, but they are making a late run that might land them in the postseason. The 49ers enter Week 16 with a record of 8-6, and they are in a great position to claim a Wild Card spot in the NFC.

Tennessee can clinch the AFC South Division with a win and a loss by the Indianapolis Colts, but they have not been playing great of late. The Titans are still 9-5 on the year, but they need to get some momentum before the playoffs begin.

The San Francisco 49ers are 3.5-point road favorites on Thursday Night Football against the Tennessee Titans.

49ers Want to Run

The San Francisco 49ers are averaging over 142 rushing yards per game, and they are going to try to win this game by running the football. San Francisco doesn't have a dominant running back in the backfield, but they try to win the time of possession battle and shorten the game with this style of play.

Quarterback Jimmy Garoppolo has thrown 18 touchdowns to just eight interceptions this season, and he has started to hit on some big plays. San Francisco will have to hit on some shots down the field to loosen up the Titans' defense.

San Francisco has held opponents to just 22.4 points per game, and that has come against some great NFC West offenses.

Tannehill Needs to Take Charge

The Titans need quarterback Ryan Tannehill to take charge of the game on Thursday night and then continue that play into the postseason. Tannehill has thrown for over 3,100 yards this season, but he also has as many interceptions as touchdown passes this season.

The Titans are still playing without running back Derrick Henry, and that has hurt the offensive production. Tennessee is still scoring 24 points per game, but that offense has been stagnant at times.

Tennessee has been giving up some big plays of late, and that could be a problem against a San Francisco team that will use the tight ends. Playing at home will give the Titans a boost, but they need to put together an entire game.

Titans Take Care of Business

The overall numbers for the 49ers and Titans are extremely similar, but Tennessee is getting a huge advantage of playing this game at home. The Titans are still playing without their best offensive player, but there is enough talent on this team to pick up a win.

San Francisco will try to run the football in this game, but they are facing a Tennessee team that has been great against the run. The Titans are going to make the 49ers throw the ball to beat them, and that's just not going to work out well for the visitors.

Both of these teams desperately need a win in this game, but it will be the home team that takes control. Bet the Tennessee Titans moneyline as they move one step closer to an AFC South Division championship with an impressive win to kick off Week 16.

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