Padres vs. Rockies Dunkel MLB Picks, Predictions and Prop Bets - April 22

The San Diego Padres aim to prolong their three-game winning streak when they take on the Colorado Rockies on Wednesday at 8:40 p.m. ET, at Coors Field. Walker Buehler (1-1, 4.58 ERA) will start for the Padres, who are 16-7 this season and second in the NL West. Tomoyuki Sugano (1-1, 3.92 ERA) is the expected starter for the Rockies, who are 9-15 and fifth in the NL West.

Despite playing on the road, the Padres are still a decent moneyline favorite (-161) over the Rockies (+135). The over/under for this contest is set at 12.

Padres vs. Rockies Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 8:40 p.m. ET
• Location: Denver, Colorado
• Stadium: Coors Field
• Favorite: Padres (-161)
• Underdog: Rockies (+135)
• Over/under: 12

How to Watch Padres vs. Rockies

• TV Channel: COLR and SDPA
• Live Stream: Fubo (Watch for free)

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Padres vs. Rockies: Betting the Moneyline

• The Padres have compiled a 9-2 record in games they were favored on the moneyline (winning 81.8% of those games).
• Colorado has won in nine, or 37.5%, of the 24 contests it has been named as odds-on underdogs in this year.
• San Diego has entered four games this season favored by -161 or more, and won each of those games.
• This season, the Rockies have been victorious six times in 20 chances when named as an underdog of at least +135 or longer on the moneyline.
• The Padres have an implied moneyline win probability of 61.7% in this game.
• The moneyline set for this matchup implies the Rockies have a 42.6% chance of coming away with a victory in the contest.

Padres vs. Rockies: Betting the Spread & Total

• The Padres have had an over/under set by bookmakers 23 times, and have combined with opponents to go over the total in nine of those games (9-12-2).
• Colorado's games have gone over the total in nine of its 24 chances.
• The Padres have gone 15-8-0 ATS this season.
• The Rockies are 15-9-0 against the spread in their 24 games with a line set by sportsbooks this season.