Padres vs. Rockies Dunkel MLB Picks, Predictions and Prop Bets - April 22

The San Diego Padres aim to prolong their three-game winning streak when they face the Colorado Rockies on Wednesday at 8:40 p.m. ET, at Coors Field. Walker Buehler (1-1, 4.58 ERA) gets the start for the Padres, who are 16-7 this season and second in the NL West. Tomoyuki Sugano (1-1, 3.92 ERA) is expected to start for the Rockies, who are 9-15 and fifth in the NL West.

The Padres are currently a moderate moneyline favorite (-159) on the road at the Rockies (+134). The contest has a total set at 12.

Padres vs. Rockies Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 8:40 p.m. ET
• Location: Denver, Colorado
• Stadium: Coors Field
• Favorite: Padres (-159)
• Underdog: Rockies (+134)
• Over/under: 12

How to Watch Padres vs. Rockies

• TV Channel: COLR and SDPA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Padres vs. Rockies: Betting the Moneyline

• The Padres are 9-2 in games they were favored on the moneyline (winning 81.8% of those games).
• Colorado has been underdogs in 24 games this season and has come away with the win nine times (37.5%) in those contests.
• San Diego has been at least -159 moneyline favorites four times this season and won each of those games.
• This year, the Rockies have won six of 20 games when listed as at least +134 or worse on the moneyline.
• Based on this game's moneyline, the Padres' implied win probability is 61.4%.
• Bookmakers have implied with the moneyline set for this matchup that the Rockies have a 42.7% chance of pulling out a win.

Padres vs. Rockies: Betting the Spread & Total

• The Padres have had an over/under set by oddsmakers 23 times, and have combined with opponents to go over the total in nine of those games (9-12-2).
• Colorado and its opponents have gone over the total this season in nine of its 24 opportunities.
• The Padres have a 15-8-0 record against the spread this season (covering 65.2% of the time).
• In 24 games with a line this season, the Rockies have a mark of 15-9-0 against the spread.