Eagles vs. 49ers NFC Wild Card Round Dunkel NFL Picks, Predictions and Odds

The Philadelphia Eagles are the favorites, expected to win by at least a field goal but less than a touchdown (currently -5.5), in their NFC Playoffs matchup versus the San Francisco 49ers. The expected point total for the game is 43.5.

On the defensive side of the ball, the Eagles have been a top-five unit, ranking fifth-best by surrendering only 19.1 points per game. They rank 19th on offense (22.3 points per game). The 49ers rank 10th in the NFL with 25.7 points per contest on offense, and they rank 13th with 21.8 points surrendered per contest on the defensive side of the ball.

Eagles vs. 49ers Odds and Game Time

• Date: Sunday, January 11, 2026
• Time: 4:30 p.m. ET
• City: Philadelphia, Pennsylvania
• Venue: Lincoln Financial Field
• Total: 43.5 points
• Spread: Eagles -5.5
• Moneyline: Eagles (-245), 49ers (+200)

How to watch Eagles vs. 49ers

• TV Channel: FOX 4K
• Live Stream: Fubo

Betting the Over/Under: Eagles vs. 49ers

• The Eagles and their opponents have gone over 43.5 combined points seven times this season.
• So far this season, seven of Philadelphia's 17 games have hit the over.
• The 49ers have played 10 games this season that ended with a combined score higher than 43.5 points.
• San Francisco and its opponent have combined to hit the over 10 out of 17 times this year.
• The two teams combine to score 48 points per game, 4.5 more points than this matchup's point total.
• Opponents of these teams average 40.9 points per game combined, 2.6 fewer than this matchup's total.

Betting the Spread: Eagles vs. 49ers

• Philadelphia has put together a 10-7-0 record against the spread this season.
• Philadelphia has covered the spread three times this season (3-3 ATS) when playing as at least 5.5-point favorites.
• The 49ers have compiled an 11-6-0 ATS record so far this season.
• San Francisco has covered the spread once this year (1-1 ATS) when playing as at least 5.5-point underdogs.
• The Eagles are 4-4 against the spread, and 5-3 overall, at home.
• Philadelphia has two wins ATS (2-2) as 5.5-point favorites or more at home.
• The 49ers are 7-2 overall, and 7-2 against the spread, in away games.
• San Francisco is unbeaten ATS (1-0) on the road as 5.5-point underdogs or more.

Betting the Moneyline: Eagles vs. 49ers

• Philadelphia is 9-6 in games they were listed as the moneyline favorite (winning 60% of those games).
• The 49ers have entered the game as underdogs five times this season and won once.
• Philadelphia is 4-2 (winning 66.7% of its games) when it have played as a moneyline favorite of -245 or shorter.
• This season, San Francisco has won one of its two games when it is the underdog by at least +200 on the moneyline.
• The implied moneyline probability in this matchup gives the Eagles a 71.0% chance to win.

Dunkel Prediction for Eagles vs. 49ers

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