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76ers vs. Cavaliers Dunkel NBA Picks, Predictions and Odds - Oct. 22

NBA Previews

22 October 2026 By Data Skrive

The Philadelphia 76ers (1-0) face the Cleveland Cavaliers (0-0) on October 22, 2026. The matchup airs on ESPN.

The 76ers are currently moderate 2.5-point favorites against the Cavaliers. The matchup has a point total of 236.5.

76ers vs. Cavaliers Odds and Game Time

Game day: Thursday, October 22, 2026
Game time: 7 p.m. ET
Location: Philadelphia, Pennsylvania
Arena: Xfinity Mobile Arena
Total: 236.5 points
Spread: 76ers -2.5
Moneyline: 76ers (-144), Cavaliers (+122)

How to watch 76ers vs. Cavaliers

TV Channel: ESPN

Betting the Over/Under: 76ers vs. Cavaliers

Bet now on FanDuel Sportsbook!

Betting the Moneyline: 76ers vs. Cavaliers

The 76ers have not played as the moneyline favorite yet this season.
Philadelphia has not yet played as a moneyline favorite of -144 or shorter.
Cleveland has not entered a game this season with longer moneyline odds than +122.
Based on this matchup's moneyline, the 76ers have an implied win probability of 59.0%.

Dunkel Index Prediction for 76ers vs. Cavaliers

Pick ATS: 76ers (- 2.5)
Pick OU: Under (236.5)
Prediction: 76ers 115 - Cavaliers 103
Check out the rest of our Dunkel Index NBA Picks!

About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.