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Penguins vs. Panthers NHL Predictions, Picks and Odds - Oct. 22

22 October 2026 By Data Skrive

Both the Pittsburgh Penguins and Florida Panthers are coming off a defeat, heading into their matchup at PPG Paints Arena on Thursday at 7 p.m. ET. The oddsmakers see this as a tight one, with the Penguins -115 to win on the moneyline, and the Panthers at -105.

Pittsburgh lost 5-4 on the road in its last game on Oct. 19 against the Utah Mammoth. Three Penguins skaters recorded two points each, including Rickard Rakell (one goal and one assist) and Erik Karlsson (one goal and one assist).

Florida played on the road in its last game on Oct. 21, and fell 5-1 against the Ottawa Senators. The Panthers got one point apiece out of three skaters in that outing, including Seth Jones (one assist) and Matthew Tkachuk (one assist).

Here is our pick for who will clinch the victory in Thursday's matchup.

Bet now on FanDuel Sportsbook!

Penguins vs. Panthers Predictions & Pick

For the upcoming contest between the Pittsburgh Penguins and Florida Panthers, computer-calculated moneyline, over/under, and score predictions are below, sourced from Dunkel Index.

  • Prediction: Panthers 4 - Penguins 3
  • Pick OU: Over 6.5 (Dunkel projecting 7 goals)

Pick with the best in the business! Get free picks for every game, every week at the Dunkel Index.

Penguins vs. Panthers Moneylines

Snag a look below at the latest moneylines for the Penguins-Panthers matchup.

  • Favorite: Penguins (-115)
  • Underdog: Panthers (-105)

Penguins Betting Insights

  • The Penguins have been a moneyline favorite two times this season (they went 0-2 in those games).
  • Pittsburgh has had moneyline odds of -115 or shorter in just two games this season, and lost both.
  • Based on this matchup's moneyline, the Penguins have an implied probability of 53.5% to win.
  • Pittsburgh's games this season have gone over this matchup's total of 6.5 goals seven times.

Panthers Betting Insights

  • This season the Panthers have been an underdog four times, and won two of those games.
  • Florida has entered three games this season as an underdog by -105 or more and is 2-1 in those contests.
  • The moneyline set in this contest implies a 51.2% chance of victory for the Panthers.
  • Florida and its opponent have combined to score over 6.5 goals in four of 10 games this season.

Penguins Key Stats

  • Pittsburgh's 32 total goals (3.2 per game) make it the 11th-ranked scoring team in the league.
  • The Penguins rank 30th in goals against, conceding 37 total goals (3.7 per game) in league action.
  • Its goal differential (-5) ranks 23rd in the league.
  • The seven power-play goals the Penguins have scored this season (10th-most in the NHL) have come on 30 power-play chances.
  • Pittsburgh is ninth in the league with a 23.33% power-play conversion rate.
  • The one shorthanded goal the Penguins have scored this season rank ninth among NHL teams.
  • Pittsburgh's 80.77% penalty-kill success rate ranks 13th in the league.
  • Pittsburgh has the 30th-ranked faceoff win percentage in the NHL, at 44.6%.
  • The Penguins connect on 11.7% of their shots (15th in the league).

Panthers Key Stats

  • Florida has 31 goals this season (3.1 per game), 12th in the league.
  • The Panthers give up three goals per game (30 in total), 18th in the league.
  • Its +1 goal differential ranks 15th in the league.
  • The Panthers have 10 power-play goals (on 48 chances), third in the NHL.
  • Florida scores on 20.83% of its power plays, No. 17 in the league.
  • The 81.4% penalty-kill percentage of Florida is 12th in the league.
  • Florida is 29th in faceoff win percentage in the NHL (45.4%).
  • The 11% shooting percentage of the Panthers is 19th in the league.

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