Yankees vs. Pirates Dunkel MLB Picks, Predictions and Prop Bets - July 22

The Pittsburgh Pirates will look for continued power from a hitter on a hot streak versus the New York Yankees on Wednesday at 1:05 p.m. ET, at Yankee Stadium. Esmerlyn Valdez is currently on a two-game homer streak. Gerrit Cole (3-5, 3.93 ERA) will start for the Yankees, who are 56-44 this season and second in the AL East. Mitch Keller (6-7, 5.14 ERA) is starting for the Pirates, who are 52-49 and third in the NL Central.

The oddsmakers have spoken, making the Yankees (-182) a moderate moneyline favorite to defeat the Pirates (+148) at home. The total in this contest is set at 9.5.

Yankees vs. Pirates Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 1:05 p.m. ET
• Location: The Bronx, New York
• Stadium: Yankee Stadium
• Favorite: Yankees (-182)
• Underdog: Pirates (+148)
• Over/under: 9.5

How to Watch Yankees vs. Pirates

• TV Channel: YES and SportsNet PT
• Live Stream: Fubo (Watch for free)

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Yankees vs. Pirates: Betting the Moneyline

• The Yankees are 48-35 in games they were favored on the moneyline (winning 57.8% of those games).
• Pittsburgh has been underdogs in 47 games this season and has come away with the win 20 times (42.6%) in those contests.
• New York is 12-7 this season when entering a game favored by -182 or more on the moneyline.
• This year, the Pirates have won two of four games when listed as at least +148 or worse on the moneyline.
• Based on this matchup's moneyline, the Yankees' implied win probability is 64.5%.
• The Pirates have an implied victory probability of 40.3% according to the moneyline set for this matchup.

Yankees vs. Pirates: Betting the Spread & Total

• The Yankees have played in 100 games with a set over/under, and have combined with their opponents to go over the total 44 times (44-52-4).
• Games involving Pittsburgh have gone over the total set by oddsmakers in 59 of 101 chances this season.
• The Yankees are 48-52-0 ATS this season.
• The Pirates have posted a record of 52-49-0 against the spread this season.