Yankees vs. Red Sox Dunkel MLB Picks, Predictions and Prop Bets - April 22

The New York Yankees will try to keep a four-game winning streak going when they visit the Boston Red Sox at 6:45 p.m. ET on Wednesday. Max Fried (2-1, 2.97 ERA) gets the start for the Yankees, who are 14-9 this season and first in the AL East. Ranger Suarez (1-1, 3.22 ERA) is starting for the Red Sox, who are 9-14 and fifth in the AL East.

Despite playing away from home the Yankees are at -136 to win, compared to the Red Sox at +115. The total for this contest is set at 7.5.

Yankees vs. Red Sox Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 6:45 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Yankees (-136)
• Underdog: Red Sox (+115)
• Over/under: 7.5

How to Watch Yankees vs. Red Sox

• TV Channel: MLB Network, NESN and Amazon Prime Video
• Live Stream: Fubo (Watch for free)

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Yankees vs. Red Sox: Betting the Moneyline

• The Yankees have been favored on the moneyline 21 total times this season. They've gone 12-9 in those games.
• Boston has been underdogs in three games this season, however, it has failed to come away with a win in any of those games.
• New York has a record of 8-7 in games when bookmakers favor them by at least -136 on the moneyline.
• The Red Sox have been listed as an underdog of +115 or more on two occasions this season and lost both games.
• The implied moneyline probablility in this matchup gives the Yankees a 57.6% chance to win.
• The moneyline set for this matchup implies the Red Sox have a 46.5% chance of walking away with the win.

Yankees vs. Red Sox: Betting the Spread & Total

• The Yankees have combined with opponents to hit the over on the total nine times this season for a 9-12-2 record against the over/under.
• Boston and its opponents have hit the over in 11 of its 23 games with a total this season.
• The Yankees have covered 52.2% of their games this season, going 12-11-0 against the spread.
• The Red Sox are 7-16-0 against the spread in their 23 games with a line set by sportsbooks this season.