Marlins vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Miami Marlins and St. Louis Cardinals square off on Wednesday at 12:10 p.m. ET at loanDepot park, attempting to break a 1-1 series tie. Janson Junk (0-2, 4.50 ERA) will start for the Marlins, who are 11-13 this season and second in the NL East. Kyle Leahy (2-2, 5.21 ERA) is starting for the Cardinals, who are 14-9 and third in the NL Central.

The Cardinals (+119) take their show on the road to face the favored Marlins (-143). The total for this contest is set at 8.5.

Marlins vs. Cardinals Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 12:10 p.m. ET
• Location: Miami, Florida
• Stadium: loanDepot park
• Favorite: Marlins (-143)
• Underdog: Cardinals (+119)
• Over/under: 8.5

How to Watch Marlins vs. Cardinals

• TV Channel: MIAM and CARD
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Marlins vs. Cardinals: Betting the Moneyline

• The Marlins have a 9-6 record in games they were favored on the moneyline (winning 60% of those games).
• St. Louis has been underdogs in 20 games this season and has come away with the win 12 times (60%) in those contests.
• Miami has entered six games this season favored by -143 or more and is 5-1 in those contests.
• This season, the Cardinals have come away with a win four times in seven chances when named as an underdog of at least +119 or longer on the moneyline.
• The Marlins have an implied moneyline win probability of 58.8% in this matchup.
• The Cardinals have an implied victory probability of 45.7% according to the moneyline set for this matchup.

Marlins vs. Cardinals: Betting the Spread & Total

• The Marlins have combined with opponents to hit the over on the total 14 times this season for a 14-9-1 record against the over/under.
• St. Louis' games have gone over the total in 12 of its 23 chances.
• The Marlins have put together a 9-15-0 record ATS this season.
• In 23 games with a line this season, the Cardinals have a mark of 13-10-0 against the spread.