Rams vs. 49ers Week 1 Dunkel NFL Picks, Predictions and Odds

This week, the NFL travels to Melbourne, Australia as the Los Angeles Rams (0-0) face the San Francisco 49ers (0-0) at Melbourne Cricket Ground on Thursday, September 10, 2026. The Rams are favorites in this one, with the spread sitting at 3.5 points. The total for this one is set at 48.5 points.

The Rams owned the 10th-ranked defense last season (20.4 points allowed per game), and they were more effective offensively, ranking best with 30.5 points per game. The 49ers compiled 25.7 points per game on offense last season, which ranked them 10th in the NFL. On defense, they ranked 13th, giving up 21.8 points per game.

Rams vs. 49ers Odds and Game Time

• Date: Thursday, September 10, 2026
• Time: 8:35 p.m. ET
• City: Melbourne, Australia
• Venue: Melbourne Cricket Ground
• Total: 48.5 points
• Spread: Rams -3.5
• Moneyline: Rams (-198), 49ers (+164)

How to watch Rams vs. 49ers

• TV Channel: Netflix

Betting the Over/Under: Rams vs. 49ers

• The Rams and their opponents went over 48.5 combined points in 10 of 17 games last season.
• Rams games hit the over 10 out of 17 times last season.
• The 49ers' games last season had a combined scoring total higher than 48.5 points in eight of 17 outings.
• San Francisco games went over the point total 10 out of 17 times last year.
• The two teams combined to score 56.2 points per game last season, 7.7 more points than this matchup's total.
• Opponents of these two teams combined to average 42.2 points per game last year, 6.3 fewer points than this contest's over/under.

Betting the Spread: Rams vs. 49ers

• Los Angeles went 12-5-0 ATS last season.
• Los Angeles was 10-4 ATS last season when playing as at least 3.5-point favorites.
• The 49ers covered 11 times in 17 matchups with a spread last year.
• San Francisco covered the spread once last season (1-2 ATS) when playing as at least 3.5-point underdogs.
• The Rams were 6-2 against the spread, and 7-1 overall, at home last year.
• At home last season, as 3.5-point favorites or more, Los Angeles was 6-2 ATS.
• The 49ers were 7-2 overall, and 7-2 against the spread, away from home last season.
• San Francisco had one win ATS (1-1) away from home as 3.5-point underdogs or more.

Betting the Moneyline: Rams vs. 49ers

• Los Angeles put together a 12-3 record in games it was favored on the moneyline last season (winning 80% of those games).
• Last season, the 49ers won one out of the five games in which they were the underdog.
• Los Angeles went 8-3 when it played as a moneyline favorite with odds of -198 or shorter (72.7%).
• San Francisco had a record of 1-1 in games where bookmakers had them as underdogs of at least +164 on the moneyline.
• The Rams have an implied moneyline win probability of 66.4% in this contest.

Dunkel Prediction for Rams vs. 49ers

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