Dodgers vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Los Angeles Dodgers visit the San Francisco Giants on Wednesday at Oracle Park, at 9:45 p.m. ET. Shohei Ohtani (2-0, 0.50 ERA) gets the start for the Dodgers, who are 16-7 this season and first in the NL West. Tyler Mahle (0-3, 7.23 ERA) is the expected starter for the Giants, who are 10-13 and fourth in the NL West.

Bookmakers have set the Dodgers as the moderate moneyline favorites (-146) on the road versus the Giants (+124). The contest has an over/under set at 7.

Dodgers vs. Giants Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Dodgers (-146)
• Underdog: Giants (+124)
• Over/under: 7

How to Watch Dodgers vs. Giants

• TV Channel: NBCS-BA and SportsNet LA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Dodgers vs. Giants: Betting the Moneyline

• The Dodgers have put together a 16-7 record in games they were favored on the moneyline (winning 69.6% of those games).
• San Francisco has been underdogs in 15 games this season and has come away with the win seven times (46.7%) in those contests.
• Los Angeles is 15-6 this season when entering a game favored by -146 or more on the moneyline.
• The Giants have a win-loss record of 2-1 when favored by +124 or worse by oddsmakers this year.
• Based on this game's moneyline, the Dodgers' implied win probability is 59.3%.
• The moneyline set for this matchup implies the Giants have a 44.6% chance of walking away with the win.

Dodgers vs. Giants: Betting the Spread & Total

• The Dodgers have had an over/under set by oddsmakers 23 times, and have combined with opponents to go over the total in 11 of those games (11-12-0).
• San Francisco's games have gone over the total in 10 of its 23 chances.
• The Dodgers have gone 12-11-0 against the spread this season.
• The Giants are 8-15-0 against the spread in their 23 games that had a posted line this season.