Dodgers vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Los Angeles Dodgers visit the San Francisco Giants on Wednesday at Oracle Park, at 9:45 p.m. ET. Shohei Ohtani (2-0, 0.50 ERA) will start for the Dodgers, who are 16-7 this season and first in the NL West. Tyler Mahle (0-3, 7.23 ERA) is expected to start for the Giants, who are 10-13 and fourth in the NL West.

Sportsbooks have set the Dodgers as the moderate moneyline favorites (-219) on the road versus the Giants (+180). The game's over/under is set at 7.5.

Dodgers vs. Giants Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Dodgers (-219)
• Underdog: Giants (+180)
• Over/under: 7.5

How to Watch Dodgers vs. Giants

• TV Channel: NBCS-BA and SportsNet LA
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Dodgers vs. Giants: Betting the Moneyline

• The Dodgers have been the moneyline favorite 23 total times this season. They've gone 16-7 in those games.
• San Francisco has been pegged as an underdog in 15 games this year and has walked away with the win seven times (46.7%) in those games.
• Los Angeles is 8-2 this season when entering a game favored by -219 or more on the moneyline.
• The Giants have yet to play a game this season with longer moneyline odds than +180.
• Based on this matchup's moneyline, the Dodgers' implied win probability is 68.7%.
• Oddsmakers have implied with the moneyline set for this matchup that the Giants have a 35.7% chance of pulling out a win.

Dodgers vs. Giants: Betting the Spread & Total

• In the 23 games in which bookmakers have set an over/under for the Dodgers, they have combined with opponents to go over the total 11 times (11-12-0).
• San Francisco and its opponents have gone over the total this season in 10 of its 23 opportunities.
• The Dodgers have a 12-11-0 record ATS this season.
• The Giants have posted a record of 8-15-0 against the spread this season.