Chargers vs. Cardinals Week 1 Dunkel NFL Picks, Predictions and Odds

The Los Angeles Chargers (0-0) are favored by 9.5 points versus the Arizona Cardinals (0-0) on September 13, 2026, starting at 4:25 p.m. ET, airing on CBS. An over/under of 47.5 points has been established for the matchup.

The Chargers ranked 20th in scoring offense (21.6 points per game) and ninth in scoring defense (20.0 points allowed per game) last year. The Cardinals had the 22nd-ranked scoring offense last year (20.9 points per game), and they were less effective on defense, ranking fourth-worst with 28.7 points allowed per game.

Chargers vs. Cardinals Odds and Game Time

• Date: Sunday, September 13, 2026
• Time: 4:25 p.m. ET
• City: Inglewood, California
• Venue: SoFi Stadium
• Total: 47.5 points
• Spread: Chargers -9.5
• Moneyline: Chargers (-500), Cardinals (+380)

How to watch Chargers vs. Cardinals

• TV Channel: CBS

Betting the Over/Under: Chargers vs. Cardinals

• In four of 17 games last season, the Chargers and their opponents went over 47.5 points.
• Chargers games went over the point total six out of 17 times last season.
• The Cardinals played 10 games last season that had more than 47.5 combined points scored.
• Arizona games went over the point total 10 out of 17 times last year.
• These teams racked up a combined 42.5 points per game last season, 5.0 fewer points than the total for this matchup.
• Combined, these teams surrendered 48.7 points per contest last year, 1.2 more points than the total for this game.

Betting the Spread: Chargers vs. Cardinals

• Los Angeles put together a 9-8-0 ATS record last year.
• Los Angeles covered the spread once when favored by 9.5 points or more last season (in two opportunities).
• The Cardinals went 6-11-0 ATS last season.
• Arizona was an underdog by 9.5 points or more four times last season, and covered the spread in one of those contests.
• The Chargers were 6-3 against the spread, and 6-3 overall, at home last season.
• At home last year, Los Angeles was unbeaten ATS (1-0) as 9.5-point favorites or more.
• Away from home last season, the Cardinals were 2-7 overall and 5-4 against the spread.
• Arizona had one win ATS (1-2) on the road as 9.5-point underdogs or more.

Betting the Moneyline: Chargers vs. Cardinals

• Los Angeles finished with a 7-5 record in games it was listed as the moneyline favorite last season (winning 58.3% of those games).
• The Cardinals won one, or 7.1%, of the 14 games they played as underdogs last season.
• Los Angeles played as a moneyline favorite of -500 or shorter in only two games last season, and it won both.
• Last season, Arizona was at least a +380 underdog on the moneyline two times, losing each of those contests.
• Based on this game's moneyline, the Chargers have an implied win probability of 83.3%.

Dunkel Prediction for Chargers vs. Cardinals

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