Chargers vs. Cardinals Week 1 Dunkel NFL Picks, Predictions and Odds

The Los Angeles Chargers (0-0) are considered favorites (-8.5) according to the oddsmakers ahead of their game against the Arizona Cardinals (0-0) on September 13, 2026, starting at 4:25 p.m. ET, airing on CBS. The expected point total for the matchup is set at 47.5.

The Chargers averaged 21.6 points per game on offense last season (20th in NFL), and they allowed 20.0 points per game (ninth) on the other side of the ball. The Cardinals averaged 325.8 yards per game on offense last year (19th in NFL), and they surrendered 357.7 yards per game (27th) on the other side of the ball.

Chargers vs. Cardinals Odds and Game Time

• Date: Sunday, September 13, 2026
• Time: 4:25 p.m. ET
• City: Inglewood, California
• Venue: SoFi Stadium
• Total: 47.5 points
• Spread: Chargers -8.5
• Moneyline: Chargers (-469), Cardinals (+360)

How to watch Chargers vs. Cardinals

• TV Channel: CBS

Betting the Over/Under: Chargers vs. Cardinals

• In four of 17 games last season, the Chargers and their opponents combined to score more than 47.5 points.
• The Chargers and their opponents combined to go over the point total six out of 17 times last season.
• The Cardinals' games last season had a combined scoring total higher than 47.5 points in 10 of 17 outings.
• Arizona games hit the over 10 out of 17 times last year.
• The teams combined to score 42.5 points per game last season, 5.0 fewer points than this matchup's total.
• These teams surrendered a combined 48.7 points per game last year, 1.2 more points than the total for this matchup.

Betting the Spread: Chargers vs. Cardinals

• Los Angeles won nine games against the spread last season, failing to cover eight times.
• Los Angeles covered the spread once when favored by 8.5 points or more last season (in two opportunities).
• The Cardinals put together a 6-11-0 ATS record last year.
• Arizona covered the spread once last year (1-3 ATS) when playing as at least 8.5-point underdogs.
• The Chargers were 6-3 overall, and 6-3 against the spread, at home last year.
• At home last year, as 8.5-point favorites or more, Los Angeles was unbeaten ATS (1-0).
• The Cardinals were 5-4 against the spread, and 2-7 overall, in away games last season.
• Arizona had one win ATS (1-2) away from home as 8.5-point underdogs or more.

Betting the Moneyline: Chargers vs. Cardinals

• Los Angeles finished with a 7-5 record in games it was listed as the moneyline favorite last season (winning 58.3% of those games).
• The Cardinals were underdogs in 14 games last season and won one (7.1%) of those contests.
• Los Angeles played as a moneyline favorite of -469 or shorter in just two games last season, and it won both.
• Last season, Arizona was at least a +360 underdog on the moneyline two times, losing each of those contests.
• Based on this contest's moneyline, the Chargers' implied win probability is 82.4%.

Dunkel Prediction for Chargers vs. Cardinals

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