Angels vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - July 22

Jo Adell rides a two-game homer streak into the Los Angeles Angels' game versus the St. Louis Cardinals at 4:07 p.m. ET on Wednesday, at Angel Stadium. Reid Detmers (3-6, 4.16 ERA) will start for the Angels, who are 41-61 this season and fifth in the AL West. Hunter Dobbins (0-0, 0.00 ERA) is expected to start for the Cardinals, who are 51-49 and fourth in the NL Central.

With the Cardinals (+103) visiting, the Angels (-125) are a solid favorite on the moneyline. The game has an over/under of 9 runs.

Angels vs. Cardinals Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 4:07 p.m. ET
• Location: Anaheim, California
• Stadium: Angel Stadium
• Favorite: Angels (-125)
• Underdog: Cardinals (+103)
• Over/under: 9

How to Watch Angels vs. Cardinals

• TV Channel: ABTV and CARD
• Live Stream: Fubo (Watch for free)

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Angels vs. Cardinals: Betting the Moneyline

• The Angels have put together a 10-10 record in games they were listed as the moneyline favorite (winning 50% of those games).
• St. Louis has won in 35, or 48.6%, of the 72 contests it has been named as odds-on underdogs in this year.
• Los Angeles has a record of 6-5 in games when oddsmakers favor them by at least -125 on the moneyline.
• This season, the Cardinals have come away with a win 26 times in 51 chances when named as an underdog of at least +103 or worse on the moneyline.
• The Angels have an implied moneyline win probability of 55.6% in this game.
• The moneyline set for this matchup implies the Cardinals have a 49.3% chance of coming away with a victory in the contest.

Angels vs. Cardinals: Betting the Spread & Total

• In the 102 games in which oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 46 times (46-52-4).
• St. Louis and its opponents have gone over the total this season in 38 of its 100 opportunities.
• The Angels have put together a 53-49-0 record against the spread this season (covering 52% of the time).
• The Cardinals have an against the spread mark of 57-43-0 in 100 games with a line this season.