Angels vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - July 22

The St. Louis Cardinals hope to end their four-game losing run versus the Los Angeles Angels, at 4:07 p.m. ET on Wednesday. Reid Detmers (3-6, 4.16 ERA) gets the start for the Angels, who are 41-61 this season and fifth in the AL West. Hunter Dobbins (0-0, 0.00 ERA) is expected to start for the Cardinals, who are 51-49 and fourth in the NL Central.

Oddsmakers have made the Angels a decent moneyline favorite (-125) at home over the Cardinals (+103). The game's over/under is 9.

Angels vs. Cardinals Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 4:07 p.m. ET
• Location: Anaheim, California
• Stadium: Angel Stadium
• Favorite: Angels (-125)
• Underdog: Cardinals (+103)
• Over/under: 9

How to Watch Angels vs. Cardinals

• TV Channel: ABTV and CARD
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Angels vs. Cardinals: Betting the Moneyline

• The Angels have been the moneyline favorite 20 total times this season. They've gone 10-10 in those games.
• St. Louis has been pegged as an underdog in 72 games this year and has walked away with the win 35 times (48.6%) in those games.
• This season Los Angeles has won six of its 11 games, or 54.5%, when favored by at least -125 on the moneyline.
• The Cardinals have a win-loss record of 26-25 when favored by +103 or worse by sportsbooks this year.
• Based on this game's moneyline, the Angels have an implied win probability of 55.6%.
• The moneyline set for this matchup implies the Cardinals have a 49.3% chance of walking away with the win.

Angels vs. Cardinals: Betting the Spread & Total

• The Angels have played in 102 games with an over/under set, and have combined with their opponents to go over the total 46 times (46-52-4).
• St. Louis and its opponents have gone over the total this season in 38 of its 100 opportunities.
• The Angels have covered 52% of their games this season, going 53-49-0 against the spread.
• The Cardinals have posted a record of 57-43-0 against the spread this season.