Astros vs. Diamondbacks Dunkel MLB Picks, Predictions and Prop Bets - Sept. 4

The Houston Astros and Arizona Diamondbacks clash in the first of a three-game series on Friday at Daikin Park, at 8:10 p.m. ET. Cristian Javier (1-5, 6.45 ERA) gets the start for the Astros, who are 72-69 this season and first in the AL West. Merrill Kelly (9-12, 5.08 ERA) is starting for the Diamondbacks, who are 74-67 and second in the NL West.

The moneyline odds for the Astros (-108) versus the Diamondbacks (-108) are tight. The game has an over/under set at 8.5 runs.

Astros vs. Diamondbacks Odds, Game Time

• Game day: Friday, September 4, 2026
• Game time: 8:10 p.m. ET
• Location: Houston, Texas
• Stadium: Daikin Park
• Favorite: Astros (-108)
• Underdog: Diamondbacks (-108)
• Over/under: 8.5

How to Watch Astros vs. Diamondbacks

• TV Channel: SCHN and ARID
• Live Stream: Fubo (Watch for free)

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Astros vs. Diamondbacks: Betting the Moneyline

• The Astros have won 30 of the 60 games they were the moneyline favorite this season (50%).
• Arizona has been victorious in 38, or 46.9%, of the 81 contests it has been chosen as underdogs in this season.
• Houston is 32-34 this season when entering a game favored by -108 or more on the moneyline.
• This season, the Diamondbacks have come away with a win 35 times in 78 chances when named as an underdog of at least -108 or longer on the moneyline.
• The implied moneyline probablility for this matchup gives the Astros a 51.9% chance to win.
• The moneyline set for this matchup implies the Diamondbacks have a 51.9% chance of coming away with a victory in the contest.

Astros vs. Diamondbacks: Betting the Spread & Total

• In the 141 games in which oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 71 times (71-61-9).
• Arizona and its opponents have gone over the total this season in 62 of its 141 opportunities.
• The Astros are 72-69-0 against the spread this season.
• The Diamondbacks are 78-63-0 against the spread in their 141 games that had a posted line this season.