It's a battle between the respective South Division leaders in Monday Night Football, although the two teams are clearly heading in opposite directions. The Carolina Panthers are off to a perfect 6-0 start despite Cam Newton's career-low completion percentage (55.8). But a defense that ranks 5th in points allowed (18.3) and has nine sacks in the last two games has led the way. For the Indianapolis Colts, little has worked right from Andrew Luck's injury-riddled season to a defense that has given up 61 points in the last two games. Yet at 3-4, the Colts still lead the anemic AFC South. To get our pick for this game, click on the Football icon above. Plus get all our selections for tonight's NBA and NHL contests as well as our latest FBS and FCS college football rankings.