Duke vs. Syracuse Dunkel Predictions & Vegas Odds - Feb. 16

In a contest featuring one of the hottest teams in college basketball, the No. 4 Duke Blue Devils (23-2, 12-1 ACC, 9-1 in their last 10) face the Syracuse Orange (15-11, 6-7 ACC) at Cameron Indoor Stadium on February 16, 2026. The Blue Devils are favorites by 20.5 points. The point total for the matchup is set at 143.5.

Duke enters this game following a 67-54 win against Clemson on Saturday. Cameron Boozer totaled 18 points, eight rebounds and four assists for Duke. Syracuse enters this game after a 79-78 win against SMU on Saturday. Donnie Freeman scored a team-high 18 points for Syracuse in the win.

Duke vs. Syracuse Odds and Game Time

• When: Monday, February 16, 2026 at 7 p.m. ET
• Where: Cameron Indoor Stadium in Durham, North Carolina
• Spread favorite: Duke -20.5
• Moneyline favorite: Duke -5882
• Moneyline underdog: Syracuse +1583
• Over/Under: 143.5 points

How to watch Duke vs. Syracuse

• TV Channel: ESPN
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. Syracuse

• This season, Duke and its opponents have combined to outscore Monday's over/under of 143.5 points 13 times.
• In Syracuse's 26 games this season, 15 finished with more combined points than Monday's total of 143.5.
• The point total for the matchup of 143.5 is 15.2 points fewer than the combined points per game averages for the Blue Devils (82.2 points per game) and the Orange (76.5 points per game).
• This game's over/under is 8.2 fewer points than the 135.3 these two teams combine to give up per game in 2024.
• Duke has a 145.4 average over/under in its games this season, 1.9 more points than the over/under in this matchup.
• The over/under for this game is 5.2 points lower than the average over/under in Syracuse's games this season (148.7 points).

Betting the Spread: Duke vs. Syracuse

• In Duke's 25 games this year, it has 13 wins against the spread.
• So far this season, the Blue Devils have been installed as favorites by a 20.5-point margin or more eight times and are 3-5 ATS in those contests.
• In Syracuse's 26 games this year, it has 14 wins against the spread.
• At home this year, Duke is 12-0 overall and 5-7 against the spread.
• At home, as a 20.5-point favorite or more, Duke has two wins ATS (2-5).
• In away games, Syracuse is 4-2 against the spread, and 2-4 overall.

Betting the Moneyline: Duke vs. Syracuse

• Duke has won 20, or 90.9%, of the 22 games it has played as the moneyline favorite this season.
• The Blue Devils have been at least a -5882 moneyline favorite five times this season and won each of those games.
• The implied probability of a win from Duke, based on the moneyline, is 98.3%.
• Syracuse has been chosen as moneyline underdogs in 11 games this year and has walked away with the win three times (27.3%) in those games.
• This is the worst odds of a win that sportsbooks have given the Orange this season with a +1583 moneyline set for this game.
• The moneyline set for this matchup implies Syracuse has a 5.9% chance of walking away with the win.