Duke vs. Louisville Dunkel Predictions & Vegas Odds - Jan. 26

The No. 4 Duke Blue Devils (18-1, 7-0 ACC) host the No. 20 Louisville Cardinals (14-5, 4-3 ACC) at Cameron Indoor Stadium, beginning at 7 p.m. ET on Monday, January 26, 2026. The Blue Devils are 8.5-point favorites in the game. The matchup's over/under is 157.5.

In its most recent matchup on Saturday, Duke earned a 90-69 victory against Wake Forest. Cameron Boozer scored a team-leading 32 points for Duke in the win. Louisville enters this game on the heels of an 85-71 win against Virginia Tech on Saturday. Mikel Brown Jr.'s team-high 20 points paced Louisville in the win.

Duke vs. Louisville Odds and Game Time

• When: Monday, January 26, 2026 at 7 p.m. ET
• Where: Cameron Indoor Stadium in Durham, North Carolina
• Spread favorite: Duke -8.5
• Moneyline favorite: Duke -455
• Moneyline underdog: Louisville +346
• Over/Under: 157.5 points

How to watch Duke vs. Louisville

• TV Channel: ESPN
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. Louisville

• Duke and its opponents have hit the over on this game's total (157.5 points) seven times this season.
• This season, eight of Louisville's games have ended with a combined score higher than 157.5 points.
• The total for the matchup of 157.5 is 16 points fewer than the combined points per game averages for the Blue Devils (85.7 points per game) and the Cardinals (87.8 points per game).
• These two teams surrender a combined 134.9 points per game, 22.6 less than this contest's over/under.
• This season the average over/under for Duke's games is 151 points, 6.5 fewer than the over/under of 157.5 set for this contest.
• The over/under for this matchup is 0.1 points more than the average over/under in Louisville's games this season (157.4 points).

Betting the Spread: Duke vs. Louisville

• Duke is 10-9-0 against the spread this season.
• This season, the Blue Devils have an against-the-spread record of 8-9 in their 17 games as a favorite of 8.5 points or more.
• Louisville has 11 wins against the spread in 19 games this season.
• At home this year, Duke is 3-6 against the spread and 9-0 overall.
• At home, Duke is 3-6 ATS as a 8.5-point favorite or more.
• Away from home, Louisville has two wins against the spread and are 2-3 overall.
• Louisville has one win ATS (1-1) away from home as 8.5-point underdogs or more.

Betting the Moneyline: Duke vs. Louisville

• Duke has been the moneyline favorite in 16 games this season and won 15 (93.8%) of those contests.
• The Blue Devils have been at least a -455 moneyline favorite 13 times this season and won each of those games.
• The sportsbooks' moneyline implies a 82% chance of a victory for Duke.
• Louisville was defeated in both of the games it has played as moneyline underdogs this season.
• This is the worst odds of a win that sportsbooks have given the Cardinals this season with a +346 moneyline set for this game.
• Sportsbooks have implied with the moneyline set for this matchup that Louisville has a 22.4% chance of pulling out a win.

Dunkel Index Prediction for Duke vs. Louisville

• Pick ATS: Duke (- 8.5)
• Pick OU: Under (157.5)
  
• Prediction: Duke 82 - Louisville 68