Creighton vs. Xavier Dunkel Predictions & Vegas Odds - Jan. 21

The Creighton Bluejays (11-8, 5-3 Big East) host the Xavier Musketeers (11-7, 3-4 Big East) at CHI Health Center Omaha, starting at 7 p.m. ET on Wednesday, January 21, 2026. The Bluejays are 8-point favorites in the game. The matchup has an over/under of 156.5 points.

In its last game on Friday, Creighton suffered a 93-88 loss to Providence. Jasen Green scored a team-leading 26 points for Creighton in the loss. Xavier's last contest on Wednesday ended in an 89-75 win over Butler. Tre Carroll put up 29 points, nine rebounds and zero assists for Xavier.

Creighton vs. Xavier Odds and Game Time

• When: Wednesday, January 21, 2026 at 7 p.m. ET
• Where: CHI Health Center Omaha in Omaha, Nebraska
• Spread favorite: Creighton -8
• Moneyline favorite: Creighton -412
• Moneyline underdog: Xavier +318
• Over/Under: 156.5 points

How to watch Creighton vs. Xavier

• TV Channel: FOX Sports 1
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Creighton vs. Xavier

• This season, eight of Creighton's 19 games have gone over Wednesday's total of 156.5 points.
• Seven of Xavier's games have finished with a combined score higher than 156.5 points this season.
• Together, the two teams combine for 155.6 points per game, 0.9 fewer points than the point total of 156.5 for this contest.
• This game's point total is 7.4 fewer points than the 149.1 these two teams combine to allow per game in 2024.
• On average, the over/under in Creighton's games is 4.9 fewer points than the over/under of 156.5 in this matchup.
• The over/under for this contest is 3.4 points higher than the average over/under in Xavier's games this season of 153.1.

Betting the Spread: Creighton vs. Xavier

• Creighton has eight wins against the spread in 19 games this year.
• The Bluejays have been favored by 8 points or more six times this season and are 3-3 ATS in those matchups.
• Xavier is 10-8-0 against the spread this year.
• This season, the Musketeers have just one ATS win in three games as an underdog of 8 points or more.
• At home this year, Creighton is 4-6 against the spread and 8-2 overall.
• At home, as a 8-point favorite or more, Creighton is 3-3 ATS.
• Xavier is 1-3 overall, with two wins against the spread, away from home.

Betting the Moneyline: Creighton vs. Xavier

• This season, Creighton has won eight out of the 10 games in which it has been the moneyline favorite.
• The Bluejays have been at least a -412 moneyline favorite five times this season and won each of those games.
• Oddsmakers have implied with the moneyline set for this matchup that Creighton has a 80.5% chance to win.
• Xavier has been chosen as moneyline underdogs in nine games this year and has walked away with the win four times (44.4%) in those games.
• The Musketeers have won all of their three games in which they were named as at least a +318 moneyline underdog.
• Bookmakers have implied with the moneyline set for this matchup that Xavier has a 23.9% chance of pulling out a win.