Guardians vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - July 22

The Minnesota Twins hope to break their four-game losing run against the Cleveland Guardians, at 6:40 p.m. ET on Wednesday. Slade Cecconi (4-6, 4.55 ERA) will start for the Guardians, who are 54-48 this season and second in the AL Central. Bailey Ober (7-3, 4.32 ERA) is expected to start for the Twins, who are 49-53 and third in the AL Central.

Bookmakers have made the Guardians a decent moneyline favorite (-126) at home over the Twins (+104). The over/under for the Guardians-Twins game is set at 8.

Guardians vs. Twins Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 6:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-126)
• Underdog: Twins (+104)
• Over/under: 8

How to Watch Guardians vs. Twins

• TV Channel: CLEG and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Twins: Betting the Moneyline

• The Guardians have gone 30-27 in games they were listed as the moneyline favorite (winning 52.6% of those games).
• Minnesota has been underdogs in 67 games this season and has come away with the win 30 times (44.8%) in those contests.
• Cleveland has entered 34 games this season favored by -126 or more and is 16-18 in those contests.
• This season, the Twins have been victorious 26 times in 55 chances when named as an underdog of at least +104 or longer on the moneyline.
• The Guardians have an implied moneyline win probability of 55.8% in this game.
• Oddsmakers have implied with the moneyline set for this matchup that the Twins have a 49% chance of pulling out a win.

Guardians vs. Twins: Betting the Spread & Total

• The Guardians have combined with opponents to hit the over on the total 48 times this season for a 48-54-0 record against the over/under.
• Minnesota and its opponents have gone over the total this season in 57 of its 102 opportunities.
• The Guardians have a 52-50-0 record against the spread this season (covering 51% of the time).
• The Twins are 53-49-0 against the spread in their 102 games with a line set by sportsbooks this season.