Guardians vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - July 22

The Minnesota Twins will look to stop a four-game losing streak when visiting the Cleveland Guardians at 6:40 p.m. ET on Wednesday. Slade Cecconi (4-6, 4.55 ERA) gets the start for the Guardians, who are 54-48 this season and second in the AL Central. Bailey Ober (7-3, 4.32 ERA) is starting for the Twins, who are 49-53 and third in the AL Central.

With the Twins (+119) visiting, the Guardians (-146) are a solid favorite on the moneyline. The game has an over/under set at 8 runs.

Guardians vs. Twins Odds, Game Time

• Game day: Wednesday, July 22, 2026
• Game time: 6:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-146)
• Underdog: Twins (+119)
• Over/under: 8

How to Watch Guardians vs. Twins

• TV Channel: CLEG and MNNT
• Live Stream: Fubo (Watch for free)

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Guardians vs. Twins: Betting the Moneyline

• The Guardians have put together a 30-27 record in games they were favored on the moneyline (winning 52.6% of those games).
• Minnesota has won in 30, or 44.8%, of the 67 contests it has been named as odds-on underdogs in this year.
• Cleveland has a record of 9-4 in games when bookmakers favor them by at least -146 on the moneyline.
• This season, the Twins have come away with a win 14 times in 32 chances when named as an underdog of at least +119 or longer on the moneyline.
• The Guardians have an implied moneyline win probability of 59.3% in this contest.
• The Twins have an implied victory probability of 45.7% according to the moneyline set by oddsmakers for this matchup.

Guardians vs. Twins: Betting the Spread & Total

• The Guardians have combined with opponents to hit the over on the total 48 times this season for a 48-54-0 record against the over/under.
• So far this season, Minnesota and its opponents have hit the over in 57 of its 102 games with a total.
• The Guardians have a 52-50-0 record against the spread this season (covering 51% of the time).
• The Twins have an against the spread record of 53-49-0 in 102 games with a line this season.