Guardians vs. Twins Dunkel MLB Picks, Predictions and Prop Bets - July 21

The Minnesota Twins will attempt to stop a three-game losing streak when visiting the Cleveland Guardians at 6:40 p.m. ET on Tuesday. Parker Messick (8-5, 2.73 ERA) gets the start for the Guardians, who are 53-48 this season and second in the AL Central. Kendry Rojas (1-1, 2.79 ERA) is expected to start for the Twins, who are 49-52 and third in the AL Central.

Bookmakers have made the Guardians a decent moneyline favorite (-152) at home over the Twins (+124). The game's over/under is set at 8.

Guardians vs. Twins Odds, Game Time

• Game day: Tuesday, July 21, 2026
• Game time: 6:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-152)
• Underdog: Twins (+124)
• Over/under: 8

How to Watch Guardians vs. Twins

• TV Channel: CLEG and MNNT
• Live Stream: Fubo (Watch for free)

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Guardians vs. Twins: Betting the Moneyline

• The Guardians are 29-27 in games they were listed as the moneyline favorite (winning 51.8% of those games).
• Minnesota has been pegged as an underdog in 66 games this year and has walked away with the win 30 times (45.5%) in those games.
• Cleveland has a record of 7-4 in games when bookmakers favor them by at least -152 on the moneyline.
• The Twins have a win-loss record of 12-14 when favored by +124 or worse by bookmakers this year.
• Based on this contest's moneyline, the Guardians have an implied win probability of 60.3%.
• The moneyline set for this matchup implies the Twins have a 44.6% chance of coming away with a victory in the contest.

Guardians vs. Twins: Betting the Spread & Total

• In the 101 games in which bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 48 times (48-53-0).
• Minnesota's games have gone over the total in 57 of its 101 chances.
• The Guardians have gone 51-50-0 ATS this season.
• The Twins have posted a record of 53-48-0 against the spread this season.