Guardians vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Cleveland Guardians and Houston Astros meet on Wednesday at 1:10 p.m. ET at Progressive Field, attempting to break a 1-1 series tie. Tanner Bibee (0-2, 4.81 ERA) gets the start for the Guardians, who are 14-11 this season and first in the AL Central. Peter Lambert (0-1, 7.20 ERA) is starting for the Astros, who are 9-16 and fifth in the AL West.

The Guardians are moderate favorites on the moneyline (-150) at home over the Astros (+127). The contest has a total set at 8.

Guardians vs. Astros Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 1:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-150)
• Underdog: Astros (+127)
• Over/under: 8

How to Watch Guardians vs. Astros

• TV Channel: CLEG and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Astros: Betting the Moneyline

• The Guardians have won 60% of the games this season when they were the moneyline favorite (6-4).
• Houston has been underdogs in nine games this season and has come away with the win four times (44.4%) in those contests.
• Cleveland has played as favorites of -150 or more once this season and won that game.
• The Astros have yet to win this season when listed as an underdog of +127 or worse on the moneyline this season.
• Based on this contest's moneyline, the Guardians' implied win probability is 60%.
• The Astros have an implied victory probability of 44.1% according to the moneyline set by oddsmakers for this matchup.

Guardians vs. Astros: Betting the Spread & Total

• The Guardians have combined with opponents to go over the total 13 times this season for a 13-12-0 record against the over/under.
• Houston's games have gone over the total in 18 of its 25 chances.
• The Guardians have a 15-10-0 record ATS this season (covering 60% of the time).
• The Astros have an against the spread record of 9-16-0 in 25 games with a line this season.