Guardians vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - April 21

Isaac Paredes leads the Houston Astros into a contest versus the Cleveland Guardians, after his two-homer showing in a 9-2 victory over the Guardians, starting at 6:10 p.m. ET on Tuesday. Parker Messick (3-0, 1.05 ERA) gets the start for the Guardians, who are 13-11 this season and first in the AL Central. Ryan Weiss (0-2, 6.75 ERA) is starting for the Astros, who are 9-15 and fifth in the AL West.

The Astros (+121) are on the road versus the favored Guardians (-145). The over/under in this contest is set at 8.5.

Guardians vs. Astros Odds, Game Time

• Game day: Tuesday, April 21, 2026
• Game time: 6:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-145)
• Underdog: Astros (+121)
• Over/under: 8.5

How to Watch Guardians vs. Astros

• TV Channel: CLEG and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Astros: Betting the Moneyline

• The Guardians have been the moneyline favorite nine total times this season. They've finished 5-4 in those games.
• Houston has won in four of the eight contests it has been named as odds-on underdogs in this year.
• Cleveland has not entered a game this season with shorter moneyline odds than -145.
• This season, the Astros have been victorious one time in four chances when named as an underdog of at least +121 or worse on the moneyline.
• The Guardians have a 59.2% chance to win this matchup based on the moneyline's implied probability.
• The Astros have an implied victory probability of 45.2% according to the moneyline set by oddsmakers for this matchup.

Guardians vs. Astros: Betting the Spread & Total

• The Guardians have played in 24 games with set over/under, and have combined with opponents to go over the total 12 times (12-12-0).
• Houston and its opponents have hit the over in 17 of its 24 games with a total this season.
• The Guardians are 14-10-0 against the spread this season.
• The Astros have an against the spread mark of 9-15-0 in 24 games with a line this season.