Guardians vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - April 20

The Cleveland Guardians and Houston Astros square off on Monday at 6:10 p.m. ET, beginning a three-game series at Progressive Field. Slade Cecconi (0-2, 5.03 ERA) will start for the Guardians, who are 13-10 this season and first in the AL Central. Spencer Arrighetti (1-0, 1.50 ERA) is the expected starter for the Astros, who are 8-15 and fifth in the AL West.

The moneyline odds for the Guardians (-115) versus the Astros (-104) indicate a tight game. The contest has a total set at 8.

Guardians vs. Astros Odds, Game Time

• Game day: Monday, April 20, 2026
• Game time: 6:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-115)
• Underdog: Astros (-104)
• Over/under: 8

How to Watch Guardians vs. Astros

• TV Channel: CLEG and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Astros: Betting the Moneyline

• The Guardians have been the moneyline favorite eight total times this season. They've finished 5-3 in those games.
• Houston has been pegged as an underdog in seven games this year and has walked away with the win three times (42.9%) in those games.
• Cleveland has a record of 5-3 when favored by -115 or more by bookmakers this season.
• This season, the Astros have come away with a win two times in six chances when named as an underdog of at least -104 or worse on the moneyline.
• The Guardians have an implied moneyline win probability of 53.5% in this contest.
• The moneyline set for this matchup implies the Astros have a 51% chance of coming away with a victory in the contest.

Guardians vs. Astros: Betting the Spread & Total

• In the 23 games in which bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 11 times (11-12-0).
• Games involving Houston have gone over the total set by oddsmakers in 16 of 23 chances this season.
• The Guardians have gone 14-9-0 ATS this season.
• The Astros have an against the spread mark of 8-15-0 in 23 games with a line this season.