White Sox vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 12

The Chicago White Sox hope to end their four-game losing run versus the St. Louis Cardinals, on Saturday at 7:15 p.m. ET. Sean Newcomb (2-4, 2.71 ERA) gets the start for the White Sox, who are 75-72 this season and first in the AL Central. Kyle Leahy (10-4, 3.41 ERA) is the expected starter for the Cardinals, who are 73-75 and fourth in the NL Central.

With moneyline odds of -111 for the White Sox and -110 for the Cardinals, this could be a close contest. The total for the White Sox-Cardinals game is set at 7.5.

White Sox vs. Cardinals Odds, Game Time

• Game day: Saturday, September 12, 2026
• Game time: 7:15 p.m. ET
• Location: St. Louis, Missouri
• Stadium: Busch Stadium
• Favorite: White Sox (-111)
• Underdog: Cardinals (-110)
• Over/under: 7.5

How to Watch White Sox vs. Cardinals

• TV Channel: CARD and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

White Sox vs. Cardinals: Betting the Moneyline

• The White Sox have been the moneyline favorite 41 total times this season. They've gone 22-19 in those games.
• St. Louis has come away with 48 wins in the 100 contests it has been listed as the underdogs in this season.
• Chicago has entered 37 games this season favored by -111 or more and is 20-17 in those contests.
• The Cardinals have a win-loss record of 48-51 when favored by -110 or worse by sportsbooks this year.
• The White Sox have a 52.6% chance to win this matchup based on the moneyline's implied probability.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 52.4% chance of pulling out a win.

White Sox vs. Cardinals: Betting the Spread & Total

• The White Sox have played in 147 games with a set over/under, and have combined with their opponents to go over the total 83 times (83-63-1).
• So far this season, St. Louis and its opponents have hit the over in 65 of its 148 games with a total.
• The White Sox have collected an 84-63-0 record ATS this season (covering 57.1% of the time).
• The Cardinals are 82-66-0 against the spread in their 148 games with a line set by sportsbooks this season.