Cubs vs. Phillies Dunkel MLB Picks, Predictions and Prop Bets - April 22

The Chicago Cubs aim to extend their seven-game winning streak when they meet the Philadelphia Phillies on Wednesday at 7:40 p.m. ET, at Wrigley Field. Matthew Boyd (1-1, 6.75 ERA) gets the start for the Cubs, who are 14-9 this season and second in the NL Central. Kyle Backhus (0-0, 5.40 ERA) is the expected starter for the Phillies, who are 8-15 and fourth in the NL East.

The Cubs are moderate favorites on the moneyline (-175) at home over the Phillies (+146). The game has an over/under of 8 runs.

Cubs vs. Phillies Odds, Game Time

• Game day: Wednesday, April 22, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-175)
• Underdog: Phillies (+146)
• Over/under: 8

How to Watch Cubs vs. Phillies

• TV Channel: MARQ and NBCS-PH+
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. Phillies: Betting the Moneyline

• The Cubs have been the moneyline favorite 17 total times this season. They've gone 10-7 in those games.
• Philadelphia has been named as the underdog four times this season but has yet to come away with a victory in any of those games.
• Chicago has a record of 2-2 when favored by -175 or more by oddsmakers this season.
• Oddsmakers have given the Phillies the worst odds of winning they have seen this season with a +146 moneyline listed for this contest.
• The Cubs have an implied moneyline win probability of 63.6% in this game.
• The Phillies have an implied victory probability of 40.7% according to the moneyline set by sportsbooks for this matchup.

Cubs vs. Phillies: Betting the Spread & Total

• The Cubs have played in 23 games with over/under set, and have combined with opponents to go over the total 13 times (13-8-2).
• Games involving Philadelphia have gone over the total set by sportsbooks in 11 of 23 chances this season.
• The Cubs have collected an 11-12-0 record against the spread this season.
• The Phillies have posted a record of 4-19-0 against the spread this season.