Red Sox vs. Yankees Dunkel MLB Picks, Predictions and Prop Bets - April 21

The Boston Red Sox host the New York Yankees to open a three-game series at Fenway Park, with first pitch at 6:45 p.m. ET on Tuesday. Connelly Early (1-0, 2.29 ERA) gets the start for the Red Sox, who are 9-13 this season and fourth in the AL East. Luis Gil (0-1, 7.00 ERA) is the expected starter for the Yankees, who are 13-9 and first in the AL East.

The sportsbooks have spoken, making the Red Sox (-124) a moderate moneyline favorite to beat the Yankees (+104) at home. The contest has an over/under set at 8.5.

Red Sox vs. Yankees Odds, Game Time

• Game day: Tuesday, April 21, 2026
• Game time: 6:45 p.m. ET
• Location: Boston, Massachusetts
• Stadium: Fenway Park
• Favorite: Red Sox (-124)
• Underdog: Yankees (+104)
• Over/under: 8.5

How to Watch Red Sox vs. Yankees

• TV Channel: TBS, NESN+ and YES
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Red Sox vs. Yankees: Betting the Moneyline

• The Red Sox have a 9-10 record in games they were favored on the moneyline (winning 47.4% of those games).
• New York came away victorious in the one game it played as the underdog this season.
• Boston has a record of 8-10, a 44.4% win rate, when favored by -124 or more by bookmakers this season.
• Oddsmakers have given the Yankees the worst odds of winning they have seen this season with a +104 moneyline listed for this contest.
• The Red Sox have a 55.4% chance to win this game based on the moneyline's implied probability.
• The Yankees have an implied victory probability of 49% according to the moneyline set by oddsmakers for this matchup.

Red Sox vs. Yankees: Betting the Spread & Total

• In the 22 games in which bookmakers have set an over/under for the Red Sox, they have combined with opponents to go over the total 11 times (11-10-1).
• New York and its opponents have gone over the total this season in nine of its 22 opportunities.
• The Red Sox have collected a 7-15-0 record ATS this season (covering only 31.8% of the time).
• The Yankees have posted a record of 11-11-0 against the spread this season.