Penn State vs. Michigan State Dunkel NCAA Football Picks, Predictions and Odds - Nov. 15

The Penn State Nittany Lions (3-6) and the Michigan State Spartans (3-6) square off with the Land Grant Trophy on the line on Saturday, November 15, 2025 at Spartan Stadium. The Nittany Lions are favored by 7 points in the game.

The Nittany Lions' last game was against the Indiana Hoosiers, and they lost by a score of 27-24.

Last time around, the Spartans fell to the Minnesota Golden Gophers, with 23-20 being the final score.

Penn State vs. Michigan State Predictions

For the upcoming contest between the Penn State Nittany Lions and Michigan State Spartans, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Nittany Lions (- 7)
• Pick OU: Over (49.5)
  
• Prediction: Nittany Lions 36 - Spartans 19

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Penn State vs. Michigan State Moneylines

Snag a look below at the latest moneylines for the Nittany Lions-Spartans game.

• Penn State Moneyline: -272
• Michigan State Moneyline: +221

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Penn State Betting Insights

• Penn State has won 25% of the games this season when it was favored on the moneyline (1-3).
• When it has played as a moneyline favorite with odds of -272 or shorter, Penn State has gone 1-2 (33.3%).
• In six of nine games this season, the Nittany Lions and their opponents have gone over 49.5 points.
• The Nittany Lions have an average total of 49.9 in their contests this year, 0.4 more points than this matchup's over/under.
• The Nittany Lions are the 57th-highest scoring team in college football this year. The Spartans have scored the 92nd-most points.

Michigan State Betting Insights

• This season, Michigan State has been listed as the underdog in five games and failed to win any of those contests.
• This season, Michigan State has been at least a +221 underdog on the moneyline four times, losing each of those contests.
• Michigan State has played seven games this season that finished with a combined score higher than 49.5 points.
• Michigan State's outings this season have a 49.7-point average over/under, 0.2 more points than this game's total.

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Key Stats for Penn State vs. Michigan State

• In their last three head-to-head bouts, Penn State has defeated Michigan State two times.
• In their most recent three head-to-head meetings, each team has covered one time (one push) with those games outpacing the total on one occasion.
• The Nittany Lions are totaling 335.7 yards per game offensively this season (110th in the FBS), and they are allowing 325.8 yards per game (34th) on the other side of the ball.
• Penn State is putting up 30.7 points per game on offense (52nd in the FBS), and ranks 53rd on the other side of the ball with 22.3 points allowed per game.
• The Spartans rank 99th with 347.7 total yards per game on offense, and they rank 68th with 371.3 total yards ceded per contest on the defensive side of the ball.
• Michigan State's defense has been a bottom-25 unit in scoring defense this season, conceding 31.4 points per game, which ranks 21st-worst in the FBS. On the offensive side of the ball, it ranks 81st with 25.6 points per contest.